{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:37:05Z","timestamp":1777502225736,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a significant association between aortic atherosclerosis and previous major cardiovascular events. Particularly, thoracic aortic atherosclerosis is closely related to the degree of coronary and carotid artery disease. Thus, there is a rationale for screening the thoracic aorta in patients who undergo a chest computed tomography (CT) for any clinical question, in order to detect patients at increased risk of cerebro-cardiovascular (CCV) events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To estimate the association between either thoracic aortic wall thickness (AWT) or aortic total calcium score (ATCS) and CCV events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and forty-eight non-cardiac patients (78 men; 67\u00b112 years) underwent chest contrast-enhanced multidetector CT (MDCT). The AWT was measured at the level of the left atrium (AWT\n                      <jats:sub>ref<\/jats:sub>\n                      ) and at the maximum AWT (AWT\n                      <jats:sub>max<\/jats:sub>\n                      ). Correlation with clinical CCV patients' history was estimated. The value of AWT\n                      <jats:sub>max<\/jats:sub>\n                      and of a semi-quantitative ATCS as a marker for CCV events was assessed using receiver-operating characteristic curve (ROC) analysis and multivariate regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 148 patients, 59% reported sedentary lifestyle, 44% hypertension, 32% smoking, 23% hypercholesterolemia, 13% family history of cardiac disease, 12% diabetes, and 10% BMI \u226530 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; 9% reported myocardial infarction, 8% aortic aneurism, 8% myocardial revascularization, and 2% ischemic stroke. Twenty-six percent of patients had a medium-to-high ATCS. Both AWT\n                      <jats:sub>max<\/jats:sub>\n                      and AWT\n                      <jats:sub>ref<\/jats:sub>\n                      correlated with hypertension and age ( P\u2009&lt;\u20090.002). At the ROC analysis, a 4.8\u2009mm threshold was associated to a 90% specificity and an odds ratio of 6.3 (AUC\u2009=\u20090.735). Assuming as threshold the AWT\n                      <jats:sub>max<\/jats:sub>\n                      median value (4.3\u2009mm) of patients who suffered from at least one CCV event in their history, a negative predictive value of 90%, a RR of 3.6 and an OR of 6.3 were found. At the multivariate regression analysis, AWT\n                      <jats:sub>max<\/jats:sub>\n                      was the only independent variable associated to the frequency of CCV events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Patients with increased thoracic AWT\n                      <jats:sub>max<\/jats:sub>\n                      on chest MDCT could be considered at risk for CCV disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185113513978","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T22:22:34Z","timestamp":1385763754000},"page":"1040-1049","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of aortic wall thickness on contrast-enhanced chest CT with major cerebro-cardiac events"],"prefix":"10.1177","volume":"55","author":[{"given":"Silvia","family":"Tresoldi","sequence":"first","affiliation":[{"name":"Servizio di Radiologia Diagnostica ed Interventistica, Azienda Ospedaliera San Paolo, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Di Leo","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Radiologia, IRCCS Policlinico San Donato, San Donato Milanese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Zoffoli","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Radiologia, Ospedale San Carlo Borromeo, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Munari","sequence":"additional","affiliation":[{"name":"Scuola di Specializzazione in Radiodiagnostica, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Primolevo","sequence":"additional","affiliation":[{"name":"Scuola di Specializzazione in Radiodiagnostica, Facolt\u00e0 di Medicina e Chirurgia, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Cornalba","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Sardanelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche per la Salute, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"bibr1-0284185113513978","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"bibr2-0284185113513978","first-page":"1664\u20131672","volume":"108","author":"Naghavi M","year":"2003","journal-title":"Circulation"},{"key":"bibr3-0284185113513978","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.10.012"},{"key":"bibr4-0284185113513978","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.11.3838"},{"key":"bibr5-0284185113513978","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02225-1"},{"key":"bibr6-0284185113513978","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312202"},{"key":"bibr7-0284185113513978","first-page":"1216\u20131221","volume":"334","author":"The French Study of Aortic Plaques in Stroke Group","year":"1996","journal-title":"N Engl J 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