{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:37:34Z","timestamp":1777502254009,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the last few years new potential applications have been developed for contrast-enhanced ultrasound (CEUS) and the management of breast diseases, but there is still some debate concerning the optimal dose to evaluate breast lesions, especially as a diagnostic tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare different CEUS doses of injected contrast agent in order to establish an optimal dose for the diagnosis of invasive breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In Group A we compared the bolus dose of 1.2\u2009mL vs. 2.4\u2009mL and in Group B we compared the bolus dose of 2.4\u2009mL vs. 4.8\u2009mL (26 and 25 invasive carcinomas, respectively). CEUS was performed in real-time contrast harmonic imaging (CHI) using a L9-3\u2009MHz probe. All examinations were recorded in a contrast side\/side imaging mode loop for 120\u2009s. Wash-in and wash-out patterns of the contrast agent were analyzed with advanced US quantification software and kinetic curves were used for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In Group B (2.4\u2009mL vs. 4.8\u2009mL), more and stronger correlation was found among kinetic parameters (area under the curve, P\u2009&lt;\u20090.00001; lognormal model parameters, \u03bc, P\u2009=\u20090.0007 and \u03c3, P\u2009&lt;\u20090.0001; mean transit time, P\u2009&lt;\u20090.0001; model-based wash-out ratios, W\n                      <jats:sub>21m<\/jats:sub>\n                      , P\u2009=\u20090.0002; W\n                      <jats:sub>50m<\/jats:sub>\n                      , P\u2009=\u20090.0001; time-to-peak, P\u2009=\u20090.005) as compared to Group A (1.2\u2009mL vs. 2.4\u2009mL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The optimal way to evaluate kinetic features of invasive breast tumors using real-time CEUS is with an injection of contrast agent of either 2.4\u2009mL or 4.8\u2009mL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185114520860","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T22:16:23Z","timestamp":1390256183000},"page":"34-41","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Contrast-enhanced ultrasound using real-time contrast harmonic imaging in invasive breast cancer: comparison of enhancement dynamics with three different doses of contrast agent"],"prefix":"10.1177","volume":"56","author":[{"given":"Ariel","family":"Saracco","sequence":"first","affiliation":[{"name":"Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Botond K","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Aspelin","sequence":"additional","affiliation":[{"name":"Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Leifland","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Breast Imaging, Unilabs Capio S:T G\u00f6ran Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ervin","family":"T\u00e1nczos","sequence":"additional","affiliation":[{"name":"Bolyai Institute, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary"},{"name":"Department of Medical Physics and Informatics, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Wilczek","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Breast Imaging, Unilabs Capio S:T G\u00f6ran Hospital, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rimma","family":"Axelsson","sequence":"additional","affiliation":[{"name":"Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"bibr1-0284185114520860","doi-asserted-by":"publisher","DOI":"10.1016\/S0221-0363(05)81492-1"},{"key":"bibr2-0284185114520860","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2008.9.3.243"},{"key":"bibr3-0284185114520860","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.05.0138"},{"key":"bibr4-0284185114520860","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000197708.77063.07"},{"key":"bibr5-0284185114520860","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2322031401"},{"key":"bibr6-0284185114520860","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1007\/s10406-004-0085-2","volume":"14","author":"Cosgrove D","year":"2004","journal-title":"Eur Radiol"},{"key":"bibr7-0284185114520860","first-page":"679","volume":"198","author":"Kedar RP","year":"1996","journal-title":"Work in progress. 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