{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:25:03Z","timestamp":1778660703285,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>For pulmonary subsolid nodules (SSNs) in patients with extrapulmonary malignancies, it is still unclear what proportion of SSNs is transient and how we can more accurately diagnose these transient SSNs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the frequency of transient SSNs and their differentiating clinical and thin-section computed tomography (CT) features in patients with extrapulmonary malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>From January 2005 to February 2012, 78 SSNs in 63 individuals (30 men and 33 women; mean age, 55.1 years \u00b1 15.5) with extrapulmonary malignancies were identified. Their clinical and thin-section CT characteristics were reviewed and compared between transient and persistent SSNs. Differentiating factors and their performance were also measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-six of the 78 SSNs (46.2%) were transient. Between transient and persistent SSNs, there were significant differences in patients\u2019 age, sex, detection mode, and the presence of eosinophilia, lesion multiplicity, lesion margin, and pleural retraction ( P\u2009&lt;\u20090.05). Multivariate analysis revealed that follow-up detected SSNs (adjusted odds ratio [OR], 38.88), multiple lesions (OR, 7.64), and an ill-defined nodular margin (OR, 11.93) were significant discriminators of transient SSNs ( P\u2009&lt;\u20090.05). Discrimination of transient SSNs was significantly better upon incorporating both clinical and thin-section CT features than using clinical features alone ( P\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Approximately half of the SSNs detected in patients with extrapulmonary malignancies were transient. Transient SSNs in these patients can be very accurately differentiated using their thin-section CT and clinical features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185114528325","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T21:12:56Z","timestamp":1394485976000},"page":"428-437","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Transient subsolid nodules in patients with extrapulmonary malignancies: their frequency and differential features"],"prefix":"10.1177","volume":"56","author":[{"given":"Won Seok","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea"},{"name":"Cancer Research Institute, Seoul National University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Sub","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yeon","family":"Wi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Mo","family":"Goo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea"},{"name":"Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea"},{"name":"Cancer Research Institute, Seoul National University, Seoul, Republic of 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