{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:38:49Z","timestamp":1777502329159,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulmonary function test (PFT) is commonly used to help diagnose chronic obstructive pulmonary disease (COPD) and other lung diseases. However, it cannot be used to evaluate regional function and morphological abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To quantitatively evaluate pulmonary perfusion imaging using dynamic contrast-enhanced (DCE) computed tomography (CT) and observe its correlations with PFT and CT volumetric parameters in COPD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      PFT and CT pulmonary perfusion examination were performed in 63 COPD patients. Perfusion defects were quantitated by calculating the CT value ratio (R\n                      <jats:sub>HU<\/jats:sub>\n                      ) between perfusion defects (HU\n                      <jats:sub>defect<\/jats:sub>\n                      ) and normal lung (HU\n                      <jats:sub>normal<\/jats:sub>\n                      ). Volumetric CT data were used to calculate emphysema index (EI), total lung volume (TLV), and total emphysema volume (TEV). Emphysematous parenchyma was defined as the threshold of lung area lower than \u2013950 HU. Correlations between R\n                      <jats:sub>HU<\/jats:sub>\n                      and TLV, TEV, EI, and PFT were assessed using Spearman correlation analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The positive rate of perfusion defects on CT perfusion images was higher than that of emphysema on CT mask images (\u03c72\u2009=\u200917.027, P\u2009&lt;\u20090.001). The Spearman correlation test showed that R\n                      <jats:sub>HU<\/jats:sub>\n                      was positively correlated with FEV\n                      <jats:sub>1<\/jats:sub>\n                      ( R\u2009=\u20090.59, P\u2009&lt;\u20090.001), FEV\n                      <jats:sub>1<\/jats:sub>\n                      % Predicted ( R\u2009=\u20090.61, P\u2009&lt;\u20090.001), FVC ( R\u2009=\u20090.47, P\u2009=\u20090.002), and FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC ( R\u2009=\u20090.65, P\u2009&lt;\u20090.001), and negatively correlated with EI ( R\u2009=\u2009\u20130.67, P\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      CT perfusion imaging is more sensitive in detecting emphysema that is inconspicuous on CT images. R\n                      <jats:sub>HU<\/jats:sub>\n                      is correlated with PFT and CT volumetric parameters, suggesting that it is more sensitive in detecting early COPD changes and may prove to be a potential predictor of focal lung function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185114535208","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T03:59:11Z","timestamp":1402459151000},"page":"573-580","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Quantitative assessment of pulmonary perfusion using dynamic contrast-enhanced CT in patients with chronic obstructive pulmonary disease: correlations with pulmonary function test and CT volumetric parameters"],"prefix":"10.1177","volume":"56","author":[{"given":"Yu","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Radiology, Changzheng Hospital of the Second Military Medical University, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Radiology, Changzheng Hospital of the Second Military Medical University, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Changzheng Hospital of the Second Military Medical University, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Changzheng Hospital of the Second Military Medical University, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Changzheng Hospital of the Second Military Medical University, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Changzheng Hospital of the Second Military Medical University, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Respiration Medicine, Changzheng Hospital of the Second Military Medical University, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiration Medicine, Changzheng Hospital of the Second Military Medical University, Shanghai, PR 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