{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:39:16Z","timestamp":1777502356999,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low-dose, time-resolved, contrast-enhanced, magnetic resonance angiography (TR-CEMRA) has been described previously; however, a comparative study between low dose TR-CEMRA and time-of-flight MRA (TOF-MRA) in the diagnosis of supra-aortic arterial stenosis has not yet been published.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To demonstrate the feasibility and effectiveness of low-dose TR-CEMRA compared with TOF-MRA, using high-resolution contrast-enhanced MRA (HR-CEMRA) as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This prospective study consisted of 30 consecutive patients. All patients underwent TOF-MRA of the neck and circle of Willis and supra-aortic HR-CEMRA, followed by supra-aortic low-dose TR-CEMRA. Gadoterate meglumine (Gd-DOTA, Dotarem\u00ae, Guerbet, Roissy CdG Cedex, France) was injected at a dose of 0.1\u2009mmol\/kg for HR-CEMRA, followed by a 0.03\u2009mmol\/kg bolus for low-dose TR-CEMRA. Three readers evaluated the assessibility and image quality, and then two readers classified each stenosis into the following categories: normal (0\u201330%), mild stenosis (31\u201350%), moderate (51\u201370%), severe (71\u201399%), and occlusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TR-CEMRA and HR-CEMRA showed a greater number of assessable arterial segments than TOF-MRA ( P\u2009&lt;\u20090.01). For TR-CEMRA, 29 cases showed within or better than the diagnostic range, whereas all 30 cases were in the diagnostic range for TOF-MRA and HR-CEMRA. For evaluation of stenosis in a total of 743 arterial segments, both TR-CEMRA and TOF-MRA results agreed with those of HR-CEMRA in 729 segments (98.1%), with excellent inter-observer agreement of TR-CEMRA; stenosis was overestimated in nine segments (1.2%) and underestimated in five segments (0.7%). For diagnosis of stenosis using 30% as the cut-off value on HR-CEMRA, the sensitivity and specificity were 88.2% and 99.3%, respectively, for the TR-CEMRA procedure, versus 94.1% and 99.6%, respectively, for TOF-MRA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low-dose TR-CEMRA is feasible and effective in the diagnosis of supra-aortic arterial stenosis, and could be more useful option than TOF-MRA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185114538426","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T23:52:50Z","timestamp":1403308370000},"page":"673-680","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Supra-aortic low-dose contrast-enhanced time-resolved magnetic resonance (MR) angiography at 3\u2009T: comparison with time-of-flight MR angiography and high-resolution contrast-enhanced MR angiography"],"prefix":"10.1177","volume":"56","author":[{"given":"Youn-Joo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology, The Catholic University of Korea, Seoul, Republic of Korea"},{"name":"Department of Radiology, Eulji University, Daejeon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bum-soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja-Sung","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bom-Yi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhee","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Seok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Lyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kook-Jin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Catholic University of Korea, Seoul, Republic of 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