{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:48:33Z","timestamp":1791146913727,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-invasive evaluation of the extent of axillary nodal involvement in early-stage breast cancer (ESBC) patients and accurate assessment of multifocality are both challenging. Few reports have explored whether 18F-fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT) might be more useful than other diagnostic methods in these contexts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To prospectively evaluate the diagnostic utility of FDG PET\/CT, contrast-enhanced, and diffusion-weighted magnetic resonance imaging (DCE-MRI and DWI), and sentinel lymph node biopsy (SNB), in detection of axillary metastatic lymph nodes in ESBC patients; and to explore the utilities of FDG PET\/CT and DCE-MRI for identification of multifocality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Twenty-four female patients (mean age, 47\u2009\u00b1\u20099.9 years; range, 24\u201368 years) with ESBC underwent whole-body FDG PET\/CT and breast MRI prior to operation. SNB and axillary lymph node dissection (ALND) were performed on all patients, as was mastectomy or wide local tumor excision. Histopathological findings served as the gold standard when evaluating either multifocality or axillary nodal involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy, of PET\/CT and DCE-MRI, used to detect multifocality, were as follows: 67%\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      78%, 100%\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      53%, 100%\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      50%, 83%\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      80%, and 88%\n                      <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                      63%. SNB afforded the highest sensitivity (93%) in terms of detection of axillary metastasis. The sensitivity, NPV, and accuracy of PET\/CT were 67%, 62%, and 75% respectively, thus higher than the equivalent values of either DCE-MRI or DWI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For assessment of multifocality in ESBC patients, highly specific results of PET\/CT should be taken into account along with DCE-MRI findings. For evaluation of axillary nodal involvement, PET\/CT has higher sensitivity, NPV, and accuracy values than DCE-MRI and DWI and may guide a surgical decision to proceed or not to SNB or ALND.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185114539786","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:05:39Z","timestamp":1405037139000},"page":"917-923","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Assessment of multifocality and axillary nodal involvement in early-stage breast cancer patients using 18F-FDG PET\/CT compared to contrast-enhanced and diffusion-weighted magnetic resonance imaging and sentinel node biopsy"],"prefix":"10.1177","volume":"56","author":[{"given":"Nurhan","family":"Ergul","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Kadioglu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyma","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serap Baskaya","family":"Yucel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhal","family":"Gucin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi Basak","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"Muslumanoglu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Bezmialem Vakif University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2571-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2008.00568.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1532-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-007-0010-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","unstructured":"Chung J Youk JH Kim JA et\u00a0al. Role of diffusion-weighted MRI: predicting axillary lymph node metastases in breast cancer. Acta Radiol. Epub ahead of print 14 November 2013. 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