{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:42:28Z","timestamp":1777502548318,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T00:00:00Z","timestamp":1423785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Accurate evaluation of the spleen is an important component of staging lymphoma, because this may have prognostic and therapeutic implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the diagnostic value of whole-body magnetic resonance imaging (MRI), including diffusion-weighted imaging (whole-body MRI-DWI) in the detection of splenic involvement in lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      This IRB approved, prospective multicenter study included a total of 107 patients with newly diagnosed, histologically proven lymphoma who underwent 1.5\u2009T whole-body MRI-DWI and FDG-PET\/CT. Whole-body MRI-DWI and FDG-PET\/CT were independently evaluated by a radiologist and a nuclear medicine physician, in a blinded manner. Splenic involvement at MRI was defined as splenic index\u2009&gt;\u2009725\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      or discrete nodules. At FDG-PET\/CT splenic involvement was defined as splenic uptake greater than liver uptake or hypodense nodules at contrast-enhanced CT. FDG-PET\/CT augmented with follow-up imaging after treatment was used as reference standard.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Splenic involvement was detected with FDG-PET\/CT in 21 patients, all demonstrating response to treatment. The sensitivity, specificity, positive predictive value, and negative predictive value of whole-body MRI-DWI for the detection of splenic involvement were 85.7 %, 96.5 %, 85.7%, and 96.5%, respectively. Three out of six discrepancies were related to suboptimal criterion of splenic size used with whole-body MRI-DWI versus the size-independent FDG uptake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Whole-body MRI-DWI is reasonably accurate in the detection of splenic lymphomatous involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185115571657","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:48:53Z","timestamp":1423874933000},"page":"142-151","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Accuracy of whole-body MRI in the assessment of splenic involvement in lymphoma"],"prefix":"10.1177","volume":"57","author":[{"given":"Annemieke S","family":"Littooij","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center Utrecht\/Wilhelmina Children's Hospital, Utrecht, the Netherlands"},{"name":"Department of Diagnostic and Interventional Imaging, KK Women's and Children's Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C","family":"Kwee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center Utrecht\/Wilhelmina Children's Hospital, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignasi","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Paediatric Radiology, Hospital Materno-Infantil Vall d'Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Granata","sequence":"additional","affiliation":[{"name":"Department of Radiology, IRCCS Giannina Gaslini Hospital, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"de Keizer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center Utrecht\/Wilhelmina Children's Hospital, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik JA","family":"Beek","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center Utrecht\/Wilhelmina Children's Hospital, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique G","family":"Hobbelink","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center Utrecht\/Wilhelmina Children's Hospital, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Fijnheer","sequence":"additional","affiliation":[{"name":"Department of Haematology, Meander Medical Center, Amersfoort, theNetherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap","family":"Stoker","sequence":"additional","affiliation":[{"name":"Department of Radiology, Academic Medical Centre, Amsterdam, theNetherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rutger AJ","family":"Nievelstein","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Medical Center Utrecht\/Wilhelmina Children's Hospital, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,2,13]]},"reference":[{"key":"bibr1-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2010.515979"},{"key":"bibr2-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0631-3"},{"key":"bibr3-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951015)76:8<1460::AID-CNCR2820760825>3.0.CO;2-Y"},{"key":"bibr4-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.154.3.3969481"},{"key":"bibr5-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1177\/028418518702800202"},{"key":"bibr6-0284185115571657","doi-asserted-by":"publisher","DOI":"10.4065\/80.8.1087"},{"key":"bibr7-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)81766-0"},{"key":"bibr8-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/31542964"},{"key":"bibr9-0284185115571657","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1160"},{"key":"bibr10-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-062-1_1"},{"key":"bibr11-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-006-0171-x"},{"key":"bibr12-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1183-0"},{"key":"bibr13-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e32832fa254"},{"key":"bibr14-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09091105"},{"key":"bibr15-0284185115571657","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.4743"},{"key":"bibr16-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1758-y"},{"key":"bibr17-0284185115571657","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.5692"},{"key":"bibr18-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24356"},{"key":"bibr19-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3114-0"},{"key":"bibr20-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.11.2218"},{"key":"bibr21-0284185115571657","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.067892"},{"key":"bibr22-0284185115571657","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.04.1249"},{"key":"bibr23-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-012-2616-7"},{"key":"bibr24-0284185115571657","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.168.3.9057518"},{"key":"bibr25-0284185115571657","first-page":"219297","volume":"2013","author":"Palas J","year":"2013","journal-title":"Radiol Res Pract"},{"key":"bibr26-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181cc25ed"},{"key":"bibr27-0284185115571657","first-page":"1072","volume":"44","author":"Rini JN","year":"2003","journal-title":"J Nucl Med"},{"key":"bibr28-0284185115571657","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200109000-00017"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185115571657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0284185115571657","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185115571657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:19:13Z","timestamp":1777389553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0284185115571657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,13]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1177\/0284185115571657"],"URL":"https:\/\/doi.org\/10.1177\/0284185115571657","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,13]]}}}