{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:14:16Z","timestamp":1777724056285,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Positron emission tomography (PET) using fluor-18-deoxyglucose (18F-FDG) with or without computed tomography (CT) is generally accepted as the most sensitive imaging modality for diagnosing recurrent differentiated thyroid cancer (DTC) in patients with negative whole body scintigraphy with iodine-131 (I-131).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the potential incremental value of ultrasound (US) over 18F-FDG-PET-CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Fifty-one consecutive patients with suspected recurrent DTC were prospectively evaluated using the following multimodal imaging protocol: (i) US before PET (pre-US) with or without fine needle biopsy (FNB) of suspicious lesions; (ii) single photon emission computed tomography (\u22653 GBq I-131) with co-registered CT (SPECT-CT); (iii) 18F-FDG-PET with co-registered contrast-enhanced CT of the neck; (iv) US in correlation with the other imaging modalities (post-US). Postoperative histology, FNB, and long-term follow-up (median, 2.8 years) were taken as composite gold standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-eight malignant lesions were identified in 34 patients. Forty lesions were located in the neck or upper mediastinum. On receiver operating characteristics (ROC) analysis, 18F-FDG-PET had a limited lesion-based specificity of 59% at a set sensitivity of 90%. Pre-US had poor sensitivity and specificity of 52% and 53%, respectively, increasing to 85% and 94% on post-US, with knowledge of the PET\/CT findings ( P\u2009&lt;\u20090.05 vs. PET and pre-US). Multimodal imaging changed therapy in 15 out of 51 patients (30%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with suspected recurrent DTC, supplemental targeted US in addition to 18F-FDG-PET-CT increases specificity while maintainin sensitivity, as non-malignant FDG uptake in cervical lesions can be confirmed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185115574298","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T21:52:39Z","timestamp":1426283559000},"page":"1350-1360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Post-PET ultrasound improves specificity of 18F-FDG-PET for recurrent differentiated thyroid cancer while maintaining sensitivity"],"prefix":"10.1177","volume":"56","author":[{"given":"Martin","family":"Biermann","sequence":"first","affiliation":[{"name":"Nuclear Medicine\/PET Center, Department of Radiology, Haukeland University Hospital, Bergen\/Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen\/Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jostein","family":"Kr\u00e5kenes","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Bergen, Bergen\/Norway"},{"name":"Section for Neuroradiology, Department of Radiology, Haukeland University Hospital, Bergen\/Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Brauckhoff","sequence":"additional","affiliation":[{"name":"Section for Endocrine Surgery, Haukeland University Hospital, Bergen\/Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Kristian","family":"Haugland","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haukeland University Hospital, Bergen\/Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Heinecke","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, University of M\u00fcnster, M\u00fcnster\/Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars A","family":"Akslen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Bergen, Bergen\/Norway"},{"name":"Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen\/Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Erik","family":"Varhaug","sequence":"additional","affiliation":[{"name":"Section for Endocrine Surgery, Haukeland University Hospital, Bergen\/Norway"},{"name":"Department of Clinical Science, University of Bergen, Bergen\/Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brauckhoff","sequence":"additional","affiliation":[{"name":"Section for Endocrine Surgery, Haukeland University Hospital, Bergen\/Norway"},{"name":"Department of Clinical Science, University of Bergen, Bergen\/Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"bibr1-0284185115574298","volume-title":"Cancer in Norway 2012. 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