{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:44:18Z","timestamp":1777502658489,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple system atrophy, cerebellar type (MSA-C) sometimes shows asymmetrical findings on magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To assess the frequency and clinical significance of asymmetrical MRI and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-ethyl cysteinate dimer perfusion (ECD) SPECT findings of the cerebellum, middle cerebellar peduncle (MCP), and pons in MSA-C patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed 28 patients with MSA-C who underwent MRI and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-ECD SPECT and evaluated laterality of atrophy and signal changes on MRI, and laterality of perfusion on\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-ECD SPECT transversely and longitudinally.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Laterality was identified for 64%, 61%, and 21% of atrophy in the cerebellum, MCP, and pons, respectively, on MRI and for 71% of atrophy in the cerebellum on perfusion SPECT. Concerning comparisons between the latest MRI and SPECT findings, laterality of cerebellar\/MCP atrophy on MRI and decreased cerebellar perfusion on SPECT was matched in 57%, mismatched in 11%, and absent in 25% of patients. On past images, MRI and SPECT showed matched laterality in 33%, mismatched laterality in 27%, no laterality in 13%, and SPECT precedent laterality in 27% of patients. Including the latest and past images, asymmetrical changes were observed in 75% of patients. We could not identify any correlation between laterality of image findings and cerebellar symptoms in most patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Asymmetrical changes on MRI and perfusion SPECT are common in MSA-C patients. Perfusion SPECT is useful for diagnosing MSA-C in the early stages from a functional perspective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185115598810","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T22:19:32Z","timestamp":1438985972000},"page":"742-749","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Significance of combined use of MRI and perfusion SPECT for evaluation of multiple system atrophy, cerebellar type"],"prefix":"10.1177","volume":"57","author":[{"given":"Fuminori","family":"Miyoshi","sequence":"first","affiliation":[{"name":"Division of Radiology, Department of Pathophysiological and Therapeutic Science, Tottori University, Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Kanasaki","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Pathophysiological and Therapeutic Science, Tottori University, Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Pathophysiological and Therapeutic Science, Tottori University, Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Fujii","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Pathophysiological and Therapeutic Science, Tottori University, Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Kaminou","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Pathophysiological and Therapeutic Science, Tottori University, Faculty of 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