{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:34:50Z","timestamp":1789220090822,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parotid glands diffusion-weighted imaging (DWI) in Sj\u00f6gren\u2019s syndrome patients have provided conflicting results currently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine if parotid gland DWI using a small region of interest (ROI) can provide diagnosis and assess therapeutic efficacy in Sj\u00f6gren\u2019s syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Twenty-three women with Sj\u00f6gren\u2019s syndrome, five with dry mouth who did not meet diagnostic criteria for Sj\u00f6gren\u2019s syndrome, and 11 healthy volunteers (controls) were evaluated with DWI. All participants received routine T1-weighted (T1W) imaging and T2-weighted (T2W) fat-suppressed imaging, and DWI. The SI ratios (SIRs) and ADC ratios (ADCRs) for parotid gland\/spinal cord were then calculated. Approximately 8\u201310 round ROIs measuring approximately 5\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      were placed on each lobe of the parotid gland, and the signal intensity (SI) was measured while avoiding fat, ducts, and blood vessels. A ROI encompassing the entire lobe of the parotid gland was also used to measure SI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using 5\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ROIs significantly higher DWI SIRs were noted in participants with Sj\u00f6gren\u2019s syndrome compared with either participants with dry mouth without Sj\u00f6gren\u2019s syndrome or healthy volunteers (all, P &lt;0.001). The difference was not related to the presence of fat. No differences were noted when the larger ROI was used. In addition, parotid gland from untreated Sj\u00f6gren\u2019s participants showed significantly higher SIRs compared with those from treated participants ( P\u2009=\u20090.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A small ROI DWI can provide morphological and functional information on the parotid gland in Sj\u00f6gren\u2019s syndrome patients, and can aid in the diagnosis and evaluation of therapeutic efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185115603245","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T19:58:33Z","timestamp":1441310313000},"page":"691-700","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Diffusion-weighted MRI findings in Sj\u00f6gren\u2019s syndrome: a preliminary study"],"prefix":"10.1177","volume":"57","author":[{"given":"Changwei","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwu","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Rheumatology and Immunology, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, PR 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