{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:47:06Z","timestamp":1777502826184,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>T2* relaxation is a primary determinant of image contrast with Gradient echo (GRE) sequences, and it has been widely used across body regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the diagnostic performance of T2* mapping in combination with T2-weighted (T2W) imaging to T2W imaging alone for prostate cancer (PCa) detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>The study included 31 patients (mean age, 62\u2009\u00b1\u20093 years; age range, 45\u201378 years) who underwent magnetic resonance imaging (MRI) at 3.0T and histological examination. Three observers with varying experience levels reviewed T2W imaging alone, T2* mapping alone, and T2W imaging combined with T2* mapping. A five-point scale was used to assess the probability of PCa in each segment on MR images. Statistical analysis was performed using Z tests after adjusting for data clustering.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The area under the curve (AUC) of T2W imaging and T2* mapping data (observer 1, 0.93; observer 2, 0.90; observer 3, 0.77) was higher than T2W imaging (observer 1, 0.84; observer 2, 0.79; observer 3, 0.69) for all observers ( P\u2009&lt;\u20090.01 in all comparisons). The AUC of T2W imaging and T2* mapping data was higher for observers 1 and 2 than for observer 3 ( P\u2009&lt;\u20090.01). The sensitivity and specificity of T2W imaging and T2* mapping data (observer 1, 95%, 85%; observer 2, 90%, 83%; and observer 3, 82%, 63%, respectively) was higher than T2W imaging (observer 1, 78%, 79%; observer 2, 76%, 72%; observer 3, 74%, 51%, respectively) for all observers ( P\u2009&lt;\u20090.01 for observer 1; P\u2009&lt;\u20090.01 for observers 2 and 3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The addition of T2* mapping to T2W imaging improved the diagnostic performance of MRI in PCa detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185116633916","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T23:43:24Z","timestamp":1456443804000},"page":"114-120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["T2* mapping combined with conventional T2-weighted image for prostate cancer detection at 3.0T MRI: a multi-observer study"],"prefix":"10.1177","volume":"58","author":[{"given":"Lian-Ming","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu-Ying","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Teng","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Rong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EM","family":"Haacke","sequence":"additional","affiliation":[{"name":"Department of Radiology, Wayne State University, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiani","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Wayne State University, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"bibr1-0284185116633916","volume-title":"Cancer facts and figures 2008","author":"American Cancer 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