{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:08Z","timestamp":1780444808384,"version":"3.54.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The apparent diffusion coefficient (ADC) has been used to assess parotid gland abnormalities in Sj\u00f6gren\u2019s syndrome (SS) patients; however, few data exist on the influence of region of interest (ROI) methods on ADC measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the influence of ROI methods on ADC measurement, and their diagnostic ability in detecting parotid gland abnormalities in early SS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Thirteen early SS patients underwent parotid gland diffusion-weighted imaging scans at a 3.0\u2009T MR unit. Two readers independently measured the parotid gland ADC value using three different ROIs (whole-gland [WG], single-slice [SS], and reader-based circular [RBC]). The ADC value based on three different ROIs (ADC-ROI\n                      <jats:sub>WG<\/jats:sub>\n                      , ADC-ROI\n                      <jats:sub>SS<\/jats:sub>\n                      , ADC-ROI\n                      <jats:sub>RBC<\/jats:sub>\n                      ) were compared between the SS group and a matched healthy control (HC) group (n\u2009=\u200919). Receiver operating characteristic (ROC) curves and intra-class correlation coefficients (ICC) were used to determine the diagnostic ability and reproducibility of the parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ADC-ROI\n                      <jats:sub>WG<\/jats:sub>\n                      , ADC-ROI\n                      <jats:sub>SS<\/jats:sub>\n                      , and ADC-ROI\n                      <jats:sub>RBC<\/jats:sub>\n                      in the SS group were all significantly higher than those in HC group (all P\u2009&lt;\u20090.05). The ADC-ROI\n                      <jats:sub>WG<\/jats:sub>\n                      showed better diagnostic ability than did ADC-ROI\n                      <jats:sub>RBC<\/jats:sub>\n                      ( P\u2009=\u20090.0200), while no significant difference was found between ADC-ROI\n                      <jats:sub>WG<\/jats:sub>\n                      and ADC-ROI\n                      <jats:sub>SS<\/jats:sub>\n                      ( P\u2009=\u20090.4636). The ROI\n                      <jats:sub>WG<\/jats:sub>\n                      method showed the best inter- and intra-reader agreement (ICC, 0.902 and 0.928, respectively), followed by ROI\n                      <jats:sub>SS<\/jats:sub>\n                      and ROI\n                      <jats:sub>RBC<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ROI methods can influence the parotid gland ADC measurements and their diagnostic ability. Considering our results, we suggest using in clinical practice single-slice ROIs to measure the ADC of the parotid gland.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185116637245","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T20:13:11Z","timestamp":1458245591000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of regions of interest methods on apparent coefficient measurement of the parotid gland in early Sj\u00f6gren\u2019s syndrome at 3T MRI"],"prefix":"10.1177","volume":"58","author":[{"given":"Xiaoquan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunning","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology, First Affiliated Hospital of Nanjing Medical 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