{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:50:25Z","timestamp":1777503025525,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T00:00:00Z","timestamp":1474588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many publications have examined the relationship between apparent diffusion coefficient (ADC) values and tumor grade in endometrial cancer. Nevertheless, none were designed to evaluate according to the histopathological type of endometrioid and non-endometrioid tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the role of diffusion-weighted imaging (DWI) in the differential diagnosis of endometrioid and non-endometrioid cancer of the uterus, by comparing them with contrast-enhanced magnetic resonance imaging (MRI) findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Institutional review board approval and informed consent were obtained. The MRI findings of 63 patients with endometrial cancer were retrospectively evaluated and divided into four groups: Grades I, II, and III endometrioid tumors, and non-endometrioid tumors. ADC values, DWI quotients (\n                      <jats:italic toggle=\"yes\">b<\/jats:italic>\n                      \u2009=\u20091000\u2009s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ), and post-contrast signal intensities between lesions and the myometrium (b1000q-Cq values) were evaluated. The one-way-ANOVA, student\u2019s t-test, Kruskal\u2013Wallis test, and receiver operating characteristic (ROC) analysis\u00a0were used for statistical evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean ADC values were 0.86\u2009\u00b1\u20090.14 in Grade I, 0.80\u2009\u00b1\u20090.7 in Grade II, 0.71\u2009\u00b1\u20090.14 in Grade III for endometrioid tumors, and 0.70\u2009\u00b1\u20090.12 in non-endometrioid tumors. There was a significant difference in ADC values between Grade I and Grade III (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.006), and non-endometrioid tumors (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.003). The difference was also significant between Grades I\u2009+\u2009II and Grade III (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.009), and non-endometrioid tumors (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.004). Besides, there was a significant difference between endometrioid and non-endometrioid tumors (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.022). However, when considering b1000q (F\u2009=\u20090.640,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.593) and Cq (\u03c7\n                      <jats:sup>2\u2009<\/jats:sup>\n                      =\u20096.233;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.101), no significant difference was detected among the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The difference in ADC values between the endometrioid and non-endometrioid tumors was statistically significant. However, the difference in DWI and contrast-enhancement findings were not statistically significant. Furthermore, the mean ADC values had an inverse relationship with tumor grade in the endometrioid cancer group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185116669873","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T22:09:37Z","timestamp":1474668577000},"page":"758-767","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Role of diffusion-weighted MRI in the differential diagnosis of endometrioid and non-endometrioid cancer of the uterus"],"prefix":"10.1177","volume":"58","author":[{"given":"Vuslat Lale","family":"Bakir","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haseki Women and Children Diseases Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baris","family":"Bakir","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul University, Istanbul Medical School, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00fckr\u00fc","family":"Sanli","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul University, Istanbul Medical School, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevda Ozel","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics Istanbul University, Istanbul Medical School, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet Cem","family":"Iyibozkurt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Haseki Women and Children Diseases Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve G\u00fclbiz","family":"Kartal","sequence":"additional","affiliation":[{"name":"Department of Radiology, Istanbul University, Istanbul Medical School, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekrem","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istanbul University, Istanbul Medical School, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20997"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e318153fd43"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.11.042"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23900"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","unstructured":"Kishimoto K Tajima S Maeda I et\u00a0al. 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In: Hoffman BL, Schorge JO, Schaffer JI, (eds). WilliamsGynecology, 2nd ed. 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