{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:52:54Z","timestamp":1777503174101,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-Hodgkin\u2019s lymphoma (NHL) accounts for around 4% of new cancer cases annually. Bone marrow involvement is important for staging and management. Fluorodeoxyglucose positron emission tomography\/computed tomography (FDG PET\/CT) is used increasingly to identify this, in addition to bone marrow biopsy (BMB), which is seen as \u201cgold\u201d reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare determination of bone marrow involvement by FDG PET\/CT against BMB in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of patients with histologically confirmed NHL at a single UK cancer center undergoing pre-treatment FDG PET\/CT and BMB between June 2010 and February 2013. Information was collected from patient notes, cancer registry, histological and imaging reports. Diagnostic accuracy of FDG PET\/CT was determined, compared to BMB as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-four patients with DLBCL and 12 with FL were included. Five DLBCL patients had bone marrow involvement on PET\/CT; all were confirmed on BMB. Three FL patients had marrow involvement on PET\/CT but not on BMB; one FL patient had positive BMB but negative PET\/CT. Using BMB as the reference standard, the sensitivity and specificity of FDG PET\/CT for detecting bone marrow involvement in DLBCL were 100% and 100%, respectively, and in FL were 0% and 72.7%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FDG PET\/CT is accurate for detection of bone marrow involvement in newly diagnosed DLBCL, but not FL. In DLBCL, positive FDG PET\/CT may negate the need for routine BMB, although BMB in addition or combination may be appropriate if this would influence management or prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185117701305","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T06:56:50Z","timestamp":1491461810000},"page":"1476-1484","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Use of FDG PET\/CT in identification of bone marrow involvement in diffuse large B cell lymphoma and follicular lymphoma: comparison with iliac crest bone marrow biopsy"],"prefix":"10.1177","volume":"58","author":[{"given":"Alexandra R","family":"Teagle","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Barton","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Charles-Edwards","sequence":"additional","affiliation":[{"name":"Department of Haematology, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Dizdarevic","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK"},{"name":"Clinical Imaging Science Centre, Brighton and Sussex Medical School, University of Brighton and Sussex, Brighton, UK"},{"name":"Brighton and Sussex Medical School, University of Sussex, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Chevassut","sequence":"additional","affiliation":[{"name":"Department of Haematology, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK"},{"name":"Brighton and Sussex Medical School, University of Sussex, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"bibr1-0284185117701305","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"bibr2-0284185117701305","first-page":"958","volume":"46","author":"Pakos EE","year":"2005","journal-title":"J Nucl Med"},{"key":"bibr3-0284185117701305","first-page":"1293","volume":"91","author":"Bain BJ","year":"2006","journal-title":"Haematologica"},{"key":"bibr4-0284185117701305","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.114710"},{"key":"bibr5-0284185117701305","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2010.11.020"},{"key":"bibr6-0284185117701305","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2623-4"},{"key":"bibr7-0284185117701305","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv304"},{"key":"bibr8-0284185117701305","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.7360"},{"key":"bibr9-0284185117701305","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318217aeff"},{"key":"bibr10-0284185117701305","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1630"},{"key":"bibr11-0284185117701305","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.5229"},{"key":"bibr12-0284185117701305","first-page":"987","volume":"329","author":"Project TIN-HsLPF","year":"1993","journal-title":"The International Non-Hodgkin\u2019s Lymphoma Factors Project. 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