{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:12:21Z","timestamp":1777547541758,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiation damage to the salivary gland is a common complication of radioiodine therapy (RIT) in the patients with differentiated thyroid cancer (DTC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the feasibility of using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) to detect radiation-induced changes of normal-appearing parotid glands in the patients after RIT for DTC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      We prospectively enrolled 20 patients with RIT-induced sialoadenitis and 20 healthy control (HC) participants. The patients were divided into intermediate and late groups, and a questionnaire was used to assess the related symptoms. IVIM MRI was scanned using nine b-values (0, 50, 100, 150, 200, 400, 600, 800, and 1000\u2009s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ). Quantitative parameters (pseudodiffusion coefficient, D*; perfusion fraction, f; tissue diffusivity, D) were obtained using a biexponential model and compared among different groups using one-way analysis of variance (ANOVA) test. Correlations between significant parameters and symptom score were assessed using Spearman\u2019s correlation analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The f and D value differed significantly (f, P\u2009=\u20090.016; D, P\u2009=\u20090.006) among different groups. Post\u00a0hoc analysis showed that f and D value of intermediate group were significantly higher than those of HC group (f, P\u2009=\u20090.012; D, P\u2009=\u20090.004), while no significant differences between late group and HC group (f, P\u2009=\u20090.852; D, P\u2009=\u20090.707). Significant positive correlation was found between f value and the total symptom score of the patients in intermediate group ( P\u2009=\u20090.028, r\u2009=\u20090.762).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The IVIM MRI might be feasible to detect the radiation-induced changes of parotid glands in the patients after RIT for DTC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185117709037","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T07:37:56Z","timestamp":1495438676000},"page":"204-211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Intravoxel incoherent motion magnetic resonance imaging of the normal-appearing parotid glands in patients with differentiated thyroid cancer after radioiodine therapy"],"prefix":"10.1177","volume":"59","author":[{"given":"Jie","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Quan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Yi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Bin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of nuclear medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei-Yun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR 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