{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:53:54Z","timestamp":1777503234893,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371516"],"award-info":[{"award-number":["81371516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501441"],"award-info":[{"award-number":["81501441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20150102"],"award-info":[{"award-number":["BK20150102"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20150109"],"award-info":[{"award-number":["BK20150109"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiation-induced parotid gland damage is a common complication of radiotherapy (RT) in patients with nasopharyngeal carcinoma (NPC), which always causes xerostomia, dysphagia, dental caries, and even sleep disorders. Early evaluation of radiation-induced parotid damage is required to facilitate early interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To early-evaluate radiation-induced parotid damage using diffusion kurtosis imaging (DKI) in patients with NPC undergoing RT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Thirty-two patients with NPC underwent DKI for parotid glands pre-RT (two weeks before RT), mid-RT (five weeks after RT began), and post-RT (four weeks after RT). Parotid volume, apparent diffusion coefficient (ADC), corrected diffusion coefficient (D), excess diffusion kurtosis coefficient (K) values, mean radiation dose, and xerostomia degrees were recorded and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During RT, parotid ADC (change rates\u2009=\u200941.3\u2009\u00b1\u200925.2% at mid-RT, 70.8\u2009\u00b1\u200934.3% at post-RT) and D (change rates\u2009=\u200941.9\u2009\u00b1\u200925.2% at mid-RT, 63.2\u2009\u00b1\u200930.2% at post-RT) increased, while parotid volume (atrophy rates\u2009=\u200931.5\u2009\u00b1\u20097.9% at mid-RT, 30.6\u2009\u00b1\u200910.3% at post-RT) and K (change rates\u2009=\u2009\u201317.8\u2009\u00b1\u200911.0% at mid-RT, \u201329.8\u2009\u00b1\u20099.0% at post-RT) decreased significantly (all P\u2009&lt;\u20090.001). At post-RT, the change rate of parotid D values was significantly positively correlated with the mean radiation dose ( r\u2009=\u20090.455, P\u2009&lt;\u20090.001). Parotid ADC, D, and K values showed excellent intra- and inter-observer agreement (intraclass correlation coefficient\u2009=\u20090.946-0.985).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Radiation-induced parotid damage in patients with NPC undergoing RT could be effectively evaluated by DKI in the early stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185117710051","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T09:35:38Z","timestamp":1494927338000},"page":"212-220","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Early evaluation of radiation-induced parotid damage with diffusion kurtosis imaging: a preliminary study"],"prefix":"10.1177","volume":"59","author":[{"given":"Nan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibo","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yan","sequence":"additional","affiliation":[{"name":"The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu Province, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"bibr1-0284185117710051","doi-asserted-by":"publisher","DOI":"10.1097\/01.cco.0000219256.37843.83"},{"key":"bibr2-0284185117710051","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.5501"},{"key":"bibr3-0284185117710051","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2006.04.014"},{"key":"bibr4-0284185117710051","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.12.051"},{"key":"bibr5-0284185117710051","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00060-C"},{"key":"bibr6-0284185117710051","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-006-1508-x"},{"key":"bibr7-0284185117710051","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.042"},{"key":"bibr8-0284185117710051","doi-asserted-by":"crossref","unstructured":"Abdel Razek AA, Mukherji S. 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