{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:03:23Z","timestamp":1790388203893,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bone remodels in response to mechanical loads and osteoporosis results from impaired ability of bone to remodel. Bone microarchitecture analysis provides information on bone quality beyond bone mineral density (BMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare subchondral bone microarchitecture parameters in the medial and lateral tibia plateau in individuals with and without fragility fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Twelve female patients (mean age\u2009=\u200958\u2009\u00b1\u200915 years; six with and six without previous fragility fractures) were examined with dual-energy X-ray absorptiometry (DXA) and 7-T magnetic resonance imaging (MRI) of the proximal tibia. A transverse high-resolution three-dimensional fast low-angle shot sequence was acquired (0.234\u2009\u00d7\u20090.234\u2009\u00d7\u20091\u2009mm). Digital topological analysis (DTA) was applied to the medial and lateral subchondral bone of the proximal tibia. The following DTA-based bone microarchitecture parameters were assessed: apparent bone volume; trabecular thickness; profile-edge-density (trabecular bone erosion parameter); profile-interior-density (intact trabecular rods parameter); plate-to-rod ratio; and erosion index. We compared femoral neck T-scores and bone microarchitecture parameters between patients with and without fragility fracture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no statistical significant difference in femoral neck T-scores between individuals with and without fracture (\u20132.4\u2009\u00b1\u20090.9 vs. \u22121.8\u2009\u00b1\u20090.7, P\u2009=\u20090.282). Apparent bone volume in the medial compartment was lower in patients with previous fragility fracture (0.295\u2009\u00b1\u20090.022 vs. 0.317\u2009\u00b1\u20090.009; P\u2009=\u20090.016). Profile-edge-density, a trabecular bone erosion parameter,\u00a0was higher in patients with previous fragility fracture in the medial (0.008\u2009\u00b1\u20090.003 vs. 0.005\u2009\u00b1\u20090.001) and lateral compartment (0.008\u2009\u00b1\u20090.002 vs. 0.005\u2009\u00b1\u20090.001); both P\u2009=\u20090.025. Other DTA parameters did not differ between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>7-T MRI and DTA permit detection of subtle changes in subchondral bone quality when differences in BMD are not evident.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185117732098","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T02:10:41Z","timestamp":1505268641000},"page":"716-722","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Subchondral bone microarchitecture analysis in the proximal tibia at 7-T MRI"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-541X","authenticated-orcid":false,"given":"Christoph A","family":"Agten","sequence":"first","affiliation":[{"name":"Center for Musculoskeletal Care, Department of Radiology, NYU School of Medicine, New York, NY, USA"},{"name":"NYU Langone Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Honig","sequence":"additional","affiliation":[{"name":"NYU Langone Medical Center, New York, NY, USA"},{"name":"Osteoporosis Center, Hospital for Joint Diseases, School of Medicine, New York University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punam K","family":"Saha","sequence":"additional","affiliation":[{"name":"Structural Imaging Laboratory, Departments of ECE and Radiology, University of Iowa, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Regatte","sequence":"additional","affiliation":[{"name":"NYU Langone Medical Center, New York, NY, USA"},{"name":"Department of Radiology, NYU School of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Musculoskeletal Care, Department of Radiology, NYU School of Medicine, New York, NY, USA"},{"name":"NYU Langone Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"bibr1-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.785"},{"key":"bibr2-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2817"},{"key":"bibr3-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060716"},{"key":"bibr4-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24927"},{"key":"bibr5-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24892"},{"key":"bibr6-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.06.001"},{"key":"bibr7-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.20"},{"key":"bibr8-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.11.1947"},{"key":"bibr9-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.10.001"},{"key":"bibr10-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1568"},{"key":"bibr11-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-014-0588-4"},{"key":"bibr12-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-011-0333-1"},{"key":"bibr13-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-2041-5"},{"key":"bibr14-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1049"},{"key":"bibr15-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090114"},{"key":"bibr16-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-010-0243-6"},{"key":"bibr17-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10138"},{"key":"bibr18-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1006\/cviu.1996.0032"},{"key":"bibr19-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1098(2000)11:1<81::AID-IMA9>3.0.CO;2-1"},{"key":"bibr20-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.8.1520"},{"key":"bibr21-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1016\/j.patrec.2015.04.006"},{"key":"bibr22-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1109\/42.845175"},{"key":"bibr23-0284185117732098","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-5-3"},{"key":"bibr24-0284185117732098","first-page":"587","volume":"72","author":"Prasad 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Correlative analysis of vertebral trabecular bone microarchitecture and mechanical properties: a combined ultra-high field (7 Tesla) MRI and biomechanical investigation. Spine (Phila Pa 1976) 2017. 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