{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:58:39Z","timestamp":1783511919597,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In\u00a0vivo magnetic resonance spectroscopy (MRS) enables non-invasive measurements of tumor metabolites. Choline-containing metabolites play a key role in tumor metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore whether preoperative MRS-derived tumor choline levels are associated with clinical and histological features in endometrial carcinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Preoperative pelvic magnetic resonance imaging (MRI) (1.5T), including structural and diffusion-weighted imaging and localized multivoxel proton MR (1H-MR) spectroscopy, was performed in 77 prospectively included patients with histologically confirmed endometrial carcinomas. Relative levels of total choline-containing metabolites (tCho) in tumor and myometrium were measured using the ratios: tCho\/Creatine; tCho\/Water; and tCho\/Noise. MRS parameters were analyzed in relation to histological subtype and grade, surgicopathological staging parameters, MRI-measured tumor volume, and tumor apparent diffusion coefficient (ADC) value and clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tumor tissue had significantly higher ratios for tCho\/Creatine, tCho\/Water, and tCho\/Noise than normal myometrial tissue ( P\u2009&lt;\u20090.001 for all). High tumor tCho\/Water ratio was significantly associated with high tumor grade in endometrioid tumors ( P\u2009=\u20090.02). Tumor tCho\/Creatine ratio was positively correlated to MRI-measured tumor volume (r\n                      <jats:sub>s<\/jats:sub>\n                      \u2009=\u20090.25; P\u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High choline levels in tumor are associated with high-risk features. In\u00a0vivo MRS may potentially aid in the preoperative risk stratification in endometrial cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185117733297","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:47:49Z","timestamp":1505868469000},"page":"497-505","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["In\u00a0vivo MR spectroscopy predicts high tumor grade in endometrial cancer"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8004-0584","authenticated-orcid":false,"given":"Sigmund","family":"Ytre-Hauge","sequence":"first","affiliation":[{"name":"Department of Radiology, Haukeland University Hospital, Bergen, Norway"},{"name":"Section for Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology \u2013 NTNU, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torill E","family":"Sj\u00f8bakk","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, Norwegian University of Science and Technology \u2013 NTNU, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Gr\u00fcner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Physics and Technology, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine","family":"Woie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway"},{"name":"Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrica M","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway"},{"name":"Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Krakstad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway"},{"name":"Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Bj\u00f8rge","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway"},{"name":"Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind O","family":"Salvesen","sequence":"additional","affiliation":[{"name":"Unit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingunn M","family":"Stefansson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haukeland University Hospital, Bergen, 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