{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:04:08Z","timestamp":1794013448732,"version":"4.8.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Conventional magnetic resonance imaging (MRI) is adversely affected by thick slices, small intersection gaps, and the partial volume effect, leading to the missed diagnosis or misdiagnosis of pituitary micro-lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the diagnostic yield of three-dimensional sampling perfection with application-optimized contrasts using different flip-angle evolutions (3D-T2 SPACE) sequences compared with a standard MRI protocol for the diagnosis of pituitary micro-lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>The MRI findings of 664 patients with clinically suspected pituitary lesions were retrospectively analyzed. All patients underwent coronal 3D-T2 SPACE sequences followed by T1-weighted (T1W) imaging. Conventional scanning sequences included coronal and sagittal T1W imaging and post-contrast enhanced coronal and sagittal T1 imaging. All images were independently evaluated by two experienced neuroradiologists. The inter-observer agreement was analyzed using kappa statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with conventional sequences, there was an increase in diagnostic confidence of 60.3% for the diagnosis of pituitary micro-lesions with the addition of 3D-T2 SPACE sequences. The lesion conspicuity scores of combined conventional and 3D-T2 SPACE sequences were significantly higher than those of conventional imaging (z\u2009=\u2009\u22126.403, P\u2009&lt;\u20090.01) and 3D-T2 SPACE sequences (z\u2009=\u2009\u22124.243, P\u2009&lt;\u20090.01). In addition, the inter-observer agreement of 3D-T2 SPACE sequences was good (\u03ba\u2009=\u20090.826).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combined with routine sequences, post-contrast enhanced 3D-T2 SPACE sequences effectively improve diagnostic confidence in the diagnosis of pituitary micro-lesions. Post-contrast enhanced 3D-T2 SPACE is suitable for detecting pico-adenomas, micro-lesions adjacent to the cavernous sinuses or sellar floor, lesions between the anterior and posterior lobes, and lesions with early phase enhancement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185118774954","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:01:40Z","timestamp":1527120100000},"page":"213-220","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Increased diagnostic confidence in the diagnosis of pituitary micro-lesions with the addition of three-dimensional sampling perfection with application-optimized contrasts using different flip-angle evolutions sequences"],"prefix":"10.1177","volume":"60","author":[{"given":"Ying","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Radiology, Huashan Hosptial, Fudan University, Shanghai 200040, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huashan Hosptial, Fudan University, Shanghai 200040, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huashan Hosptial, Fudan University, Shanghai 200040, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huashan Hosptial, Fudan University, Shanghai 200040, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-2367","authenticated-orcid":false,"given":"ZhenWei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huashan Hosptial, Fudan University, Shanghai 200040, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"bibr1-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22342"},{"key":"bibr2-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.06.011"},{"key":"bibr3-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.01.012"},{"key":"bibr4-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0085-0"},{"key":"bibr5-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2015.04.010"},{"key":"bibr6-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1432-1"},{"key":"bibr7-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000191"},{"key":"bibr8-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-014-0599-0"},{"key":"bibr9-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.11.006"},{"key":"bibr10-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2014.08.011"},{"key":"bibr11-0284185118774954","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2994"},{"key":"bibr12-0284185118774954","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2015.10.018"},{"key":"bibr13-0284185118774954","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4387"},{"key":"bibr14-0284185118774954","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2833"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185118774954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0284185118774954","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185118774954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:21:55Z","timestamp":1777389715000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0284185118774954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,23]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1177\/0284185118774954"],"URL":"https:\/\/doi.org\/10.1177\/0284185118774954","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,23]]}}}