{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:41:57Z","timestamp":1790538117365,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T00:00:00Z","timestamp":1527379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Neuromelanin magnetic resonance imaging (NmMRI) and\n                      <jats:sup>123<\/jats:sup>\n                      I-FP-CIT dopamine transporter single photon emission computed tomography (DAT-SPECT) provide specific information that distinguishes Parkinson's disease (PD) from non-degenerative parkinsonian syndrome (NDPS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine whether a multiparametric scoring system (MSS) could improve accuracy compared to each parameter of DAT-SPECT and NmMRI in differentiating PD from NDPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A total of 49 patients, including 14 with NDPS, 30 with PD, and five with atypical parkinsonian disorder (APD) underwent both NmMRI and DAT-SPECT and were evaluated. The average (Ave) and the asymmetry index (AI) were calculated in the substantia nigra compacta area (SNc-area), SNc midbrain-tegmentum contrast ratio (SNc-CR), and specific binding ratio (SBR). Cut-off values were determined, using receiver operating characteristic (ROC) analysis, for the differentiation of PD from NDPS on the statistically significant parameters. All cases were scored as either 1 (PD) or 0 (NDPS) for each parameter according to its threshold. These individual scores were totaled for each case, yielding a combined score for each case to obtain a cut-off value for the MSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Ave-SNc-area, Ave-SNc-CR, and Ave-SBR in PD were significantly lower than those in NDPS. The AI-SNc-area and AI-SBR in PD were significantly higher than those in NDPS. Of the five parameters, the highest accuracy was 93% for the Ave-SNc-area. For the MSS, a cut-off value of 3 was the accuracy of 96%. Besides, no significant difference was observed between PD and APD on all parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An MSS has comparable or better accuracy compared to each parameter of DAT-SPECT and NmMRI in distinguishing PD from NDPS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185118778871","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T01:01:50Z","timestamp":1527469310000},"page":"230-238","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["The utility of the combined use of\n                    <sup>123<\/sup>\n                    I-FP-CIT SPECT and neuromelanin MRI in differentiating Parkinson's disease from other parkinsonian syndromes"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-1600","authenticated-orcid":false,"given":"Eiji","family":"Matsusue","sequence":"first","affiliation":[{"name":"Department of Radiology, Tottori Prefectural Central Hospital, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Fujihara","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tottori Prefectural Central Hospital, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tottori prefectural Central Hospital, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Aozasa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tottori prefectural Central Hospital, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tottori prefectural Central Hospital, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakayasu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tottori prefectural Central Hospital, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tottori Prefectural Central Hospital, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Pathophysiological Therapeutic Science, Tottori University, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,27]]},"reference":[{"key":"bibr1-0284185118778871","first-page":"439","volume":"18","author":"Nikolaus S","year":"2007","journal-title":"Rev Neurosci"},{"key":"bibr2-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.06.008"},{"key":"bibr3-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.157370"},{"key":"bibr4-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304436"},{"key":"bibr5-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)91429-7"},{"key":"bibr6-0284185118778871","first-page":"359","volume":"103","author":"Graham DG","year":"1979","journal-title":"Arch Pathol Lab Med"},{"key":"bibr7-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.512"},{"key":"bibr8-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000227984.84927.a7"},{"key":"bibr9-0284185118778871","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3567"},{"key":"bibr10-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23722"},{"key":"bibr11-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.08.043"},{"key":"bibr12-0284185118778871","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00196"},{"key":"bibr13-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-016-1644-7"},{"key":"bibr14-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1177\/0284185117722812"},{"key":"bibr15-0284185118778871","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"bibr16-0284185118778871","doi-asserted-by":"crossref","unstructured":"Gilman S, Wenning GK, Low PA, et al. 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