{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:06:29Z","timestamp":1793225189840,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Kore","award":["2017R1A2B4004951"],"award-info":[{"award-number":["2017R1A2B4004951"]}]},{"name":"Seoul National University Hospital Research Fund","award":["04-2015-0520"],"award-info":[{"award-number":["04-2015-0520"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kupffer cells (KC) have an important role in the host defense in obstructive cholangitis. Non-invasive monitoring of phagocytic function of KC is pivotal. Several studies showed the possibility of non-invasive monitoring of phagocytic function of KC using superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI) or contrast-enhanced ultrasound (CEUS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the serial change of KC function using SPIO-MRI and CEUS and whether the SPIO-MRI parameter correlates with the CEUS parameter in obstructive cholangitis rat models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>With our institutional Animal Care and Use Committee approval, 19 rats (common bile duct ligation [CBDL]: n\u2009=\u20099; control: n\u2009=\u200910) underwent SPIO-MRI and CEUS at baseline, two, and four weeks after CBDL. The relative signal loss (RSL) of T2* value on SPIO-MRI and Kupffer phase parenchymal echogenicity (KPE) on CEUS were measured. The correlation between SPIO-MRI and CEUS parameters were compared with KC count.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In CBDL group, RSL and KPE had significantly decreased (72.1% to 29.5%, 2.7 to 0.4) at four weeks compared with those in the control group (68.2% to 58.3%, 2.5 to 3.0, P\u2009&lt;\u20090.05). During the follow-up period, RSL showed significantly positive correlations with KPE ( P\u2009=\u20090.007). In addition, at four weeks, we found RSL was positively correlated with KPE (\u03c1\u2009=\u20090.750, P\u2009=\u20090.002). KC count was negatively correlated to RSL and KPE at four weeks (\u03c1\u2009=\u2009\u22120.771, P\u2009=\u20090.001 and \u03c1\u2009=\u2009\u22120.644, P\u2009=\u20090.013).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SPIO-MRI and CEUS may be equally useful for monitoring the serial changes of KC phagocytic function in\u00a0vivo.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185118784978","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T12:01:23Z","timestamp":1553169683000},"page":"407-414","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Monitoring of impaired phagocytic function of Kupffer cells in an obstructive cholangitis rat model using superparamagnetic iron oxide MRI and contrast-enhanced ultrasound"],"prefix":"10.1177","volume":"60","author":[{"given":"Jae Hwan","family":"Lee","sequence":"first","affiliation":[{"name":"Center for Liver Cancer, National Cancer Center, Goyang, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-7758","authenticated-orcid":false,"given":"Jung Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Koo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea"},{"name":"Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,6,26]]},"reference":[{"key":"bibr1-0284185118784978","doi-asserted-by":"publisher","DOI":"10.1148\/rg.297095051"},{"key":"bibr2-0284185118784978","first-page":"97","volume":"57","author":"Navaneethan U","year":"2011","journal-title":"Minerva Gastroenterol Dietol"},{"key":"bibr3-0284185118784978","first-page":"121","volume":"7","author":"Mosler P","year":"2011","journal-title":"Gastroenterol Hepatol 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