{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:59:43Z","timestamp":1777503583078,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The region of Southern Denmark and the Council of Radiographers supported this study"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ultrasound elastography is increasingly available in clinical practice. Recent studies showed higher velocity stiffness in testicular tumors compared to normal testicles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate ultrasound elastography in combination with the apparent diffusion coefficient measurements in diffusion weighted (DW) magnetic resonance imaging (MRI) in testicles. DW can be a useful tool in evaluating testicular malignancies. However, the relationship between velocity stiffness and MRI diffusion is not well established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We prospectively included 132 patients with testicular microlithiasis (n\u2009=\u200953), or normal testicular tissue (n\u2009=\u200953), or suspected for testicular cancer (n\u2009=\u200926). All 132 patients underwent ultrasonography including shear wave elastography and MRI diffusion coefficient examination of the scrotum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No clinically relevant difference in velocity stiffness was found between normal and testicles with microlithiasis. There was a significant difference in stiffness between patients with testicular microlithiasis (0.78\u2009m\/s), normal testicular tissue (0.77\u2009m\/s), and patients with testicular cancer (1.95\u2009m\/s) ( P\u2009\u2264\u20090.001). Similarly, there was a statistically significant difference in MRI diffusion values between patients with testicular microlithiasis (0.978\u2009\u00d7\u200910\n                      <jats:sup>\u22123\u2009<\/jats:sup>\n                      mm\n                      <jats:sup>2\u2009<\/jats:sup>\n                      s\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), normal testicular tissue (0.929\u2009\u00d7\u200910\n                      <jats:sup>\u22123\u2009<\/jats:sup>\n                      mm\n                      <jats:sup>2\u2009<\/jats:sup>\n                      s\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), and testicular cancers (0.743\u2009\u00d7\u200910\n                      <jats:sup>\u22123\u2009<\/jats:sup>\n                      mm\n                      <jats:sup>2\u2009<\/jats:sup>\n                      s\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) ( P\u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with testicular microlithiasis had no malignant characteristics measured with shear wave elastography or MRI diffusion. MRI diffusion and elastography may be useful to preoperatively differentiate benign from malignant testicular lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185118786063","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T11:54:11Z","timestamp":1530618851000},"page":"535-541","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Elastography and diffusion-weighted MRI in patients with testicular microlithiasis, normal testicular tissue, and testicular cancer: an observational study"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5167-7968","authenticated-orcid":false,"given":"Malene Roland","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Radiology, Clinical Cancer Centre, Vejle Hospital, Part of Lillebaelt Hospital, Vejle, Denmark"},{"name":"Urological Research Centre, Clinical Cancer Centre, Vejle Hospital, Part of Lillebaelt Hospital, Vejle, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palle J\u00f8rn","family":"Sloth Osther","sequence":"additional","affiliation":[{"name":"Urological Research Centre, Clinical Cancer Centre, Vejle Hospital, Part of Lillebaelt Hospital, Vejle, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik Dahl","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Clinical Cancer Centre, Vejle Hospital, Part of Lillebaelt Hospital, Vejle, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vedsted","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Research Unit for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark"},{"name":"Cancer Epidemiology and Population Health, King\u2019s College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren Rafael","family":"Rafaelsen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Cancer Centre, Vejle Hospital, Part of Lillebaelt Hospital, Vejle, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, Odense, 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