{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:41:37Z","timestamp":1777506097607,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography\/computed tomography (PET\/CT) has been widely used for diagnosis and staging of disease recurrence in breast cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the validity of 18F-FDG PET\/CT maximum standardized uptake value (SUVmax) of primary breast cancer (SUVmax-T) as a prognostic factor for locoregional axillary lymph node metastasis (ALNM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We prospectively studied 198 female patients with pathologically proven breast cancer. All patients were submitted to 18F-FDG PET\/CT imaging for their initial tumor staging. The SUVmax-T on 18F-FDG PET\/CT and ALNM were assessed. The patients were categorized into two groups; group A, with ALNM, and group B, without ALNM, according to the presence of locoregional ALNM on visual analysis of 18F-FDG PET\/CT. The correlations and differences between two groups were statistically evaluated. The optimal cut-off value of SUVmax-T was determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean tumor size in group A was significantly greater than that in group B ( P\u2009=\u20090.0416). The mean SUVmax-T value in group A was significantly higher than that in group B ( P\u2009=\u20090.0037). Tumor stage in group A was higher than that in group B ( P\u2009=\u20090.0045). The correlation between tumor size and SUVmax-T value was statistically significant in group A (r\u2009=\u20090.6768, P\u2009=\u20090.0111) and in group B ( r\u2009=\u20090.7221, P\u2009=\u20090.0280). The optimal cut-off of SUVmax-T for detecting ALNM was &gt;4.2. As regards molecular subtypes, the mean SUVmax-T values of HER2-positive and triple-negative subtypes in group A were significantly higher than that in group B ( P\u2009=\u20090.0012 and &lt;0.001, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Breast cancer patients with higher primary tumor 18F-FDG uptake are at greater risk of concurrent ALNM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185118824770","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T23:21:36Z","timestamp":1549322496000},"page":"1241-1250","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Is FDG maximum standardized uptake value of primary breast cancer a prognostic factor for locoregional axillary lymph node metastasis?"],"prefix":"10.1177","volume":"60","author":[{"given":"Rania","family":"Refaat","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9075-8020","authenticated-orcid":false,"given":"Mohammad","family":"Abd Alkhalik Basha","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Zagazig University, Zagazig, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Sobhi Hassan","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha S","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania M","family":"Al-Molla","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Zagazig University, Zagazig, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahla M","family":"Awad","sequence":"additional","affiliation":[{"name":"Early Cancer Detection Unit, Ain Shams University hospitals, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engi","family":"Elkholy","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"bibr1-0284185118824770","first-page":"e2235","volume":"10","author":"Power 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