{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:54:20Z","timestamp":1791906860607,"version":"4.3.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatic fibrosis is a dynamic, reversible process which can result in liver failure. Diagnosis and monitoring of hepatic fibrosis are clinically important.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the diagnostic performance of diffusion kurtosis imaging (DKI), intravoxel incoherent motion (IVIM), and monoexponential diffusion-weighted imaging (DWI) to detect clinically significant fibrosis (\u2265\u2009F2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study was approved by Institutional Review Board and the requirement of informed consent was waived. One hundred and six patients were included who underwent liver multiple b-value DWI (10 b-values at 0\u20131000 s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ) at 1.5 T and were histologically diagnosed with hepatic fibrosis. Apparent diffusion coefficient (ADC), DKI-derived apparent kurtosis ( Kapp) and diffusivity ( Dapp), and IVIM-derived true diffusion ( Dt), pseudodiffusion ( D*), and perfusion fraction ( f) were compared between no or early fibrosis (F0\u20131, n\u2009=\u200919) and clinically significant fibrosis (\u2265\u2009F2, n\u2009=\u200987). Diagnostic performance was evaluated with receiver operating characteristic (ROC) analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      F2\u20134 had a significantly lower D* (59.9\u00b116.3 vs. 86.2\u00b121.0 [\u00d710\n                      <jats:sup>\u22123<\/jats:sup>\n                      \u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s]) and Dapp (3.46\u00b10.79 vs. 4.07\u2009\u00b1\u20090.76 [\u00d710\n                      <jats:sup>\u22123<\/jats:sup>\n                      \u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s]) but higher Kapp (1.10\u00b10.18 vs. 0.98\u00b10.12) than F0\u20131 ( P\u2009&lt;\u20090.01). ADC, Dt, and f did not show significant difference between two groups ( P\u2009&gt;\u20090.05). The area under the ROC curve for diagnosis of clinically significant fibrosis (\u2265\u2009F2) was significantly larger in D* (0.89; 95% CI\u2009=\u20090.81\u20130.94) than Dapp (0.73; 95% CI\u2009=\u20090.63\u20130.81) and Kapp (0.75; 95% CI\u2009=\u20090.65\u20130.83) ( P\u2009=\u20090.017 and 0.012, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IVIM-DWI might be more suitable for detecting hepatic fibrosis than the monoexponential and kurtosis model, and D* showed a better diagnostic performance to detect clinically significant fibrosis than other parameters.<\/jats:p>\n                  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