{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:25:21Z","timestamp":1793924721830,"version":"4.8.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2016YFC0100300"],"award-info":[{"award-number":["2016YFC0100300"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771810, 81471631 and 51706178"],"award-info":[{"award-number":["81771810, 81471631 and 51706178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) treatment of uterine fibroids, the immediate ablation response is significantly affected by blood perfusion. The variability of measurement for blood perfusion is critical due to the inherent non-uniformity of tumor perfusion and its dependence on reproducible region of interest (ROI) placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the value of whole-tumor ROI (ROIwt) analysis for quantitative perfusion in predicting immediate ablation response of uterine fibroids in MR-HIFU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Thirty-one fibroids in 28 eligible patients were treated with MR-HIFU. Quantitative perfusion parameters (K\n                      <jats:sup>trans<\/jats:sup>\n                      , K\n                      <jats:sub>ep<\/jats:sub>\n                      , and V\n                      <jats:sub>p<\/jats:sub>\n                      ) derived from dynamic contrast-enhanced MRI were obtained before MR-HIFU treatment. The ROIwt and single-layer ROI (ROIsl) were used for quantitative perfusion analysis. T1 contrast-enhanced MRI immediately after MR-HIFU treatment was conducted to determine the non-perfused volume ratio (NPVR). Intraclass correlation coefficient (ICC) was used for consistency test. Spearman\u2019s correlation and multivariate linear regression were used to investigate the predictors of the NPVR. Received operating characteristic (ROC) curve was used to test the predictive efficacy of quantitative perfusion parameter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The intra- and inter-observer ICC of the quantitative perfusion parameters from ROIwt were higher than those from ROIsl. Multivariate analysis showed that the K\n                      <jats:sup>trans<\/jats:sup>\n                      of ROIwt was a predictor of the immediate ablation response. ROC analysis displayed that the AUC of K\n                      <jats:sup>trans<\/jats:sup>\n                      of ROIwt is 0.817 in predicting the ablation response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Pretreatment K\n                      <jats:sup>trans<\/jats:sup>\n                      of ROIwt is more reliable and stable than that of ROIsl. It could be a predictor for the immediate ablation response of uterine fibroids in MR-HIFU.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185119891692","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T23:41:02Z","timestamp":1574984462000},"page":"1125-1133","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response"],"prefix":"10.1177","volume":"61","author":[{"given":"Chenxia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, the Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi\u2019an Jiaotong University. Xi\u2019an, PR China"},{"name":"Department of Radiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University. Xi\u2019an, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University. Xi\u2019an, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, the Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi\u2019an Jiaotong University. Xi\u2019an, PR China"},{"name":"Department of Radiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University. Xi\u2019an, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University. Xi\u2019an, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University. Xi\u2019an, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University. Xi\u2019an, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-5896","authenticated-orcid":false,"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, the Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi\u2019an Jiaotong University. Xi\u2019an, PR China"},{"name":"Department of Radiology, The First Affiliated Hospital of Xi\u2019an Jiaotong University. 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