{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:38:53Z","timestamp":1790480333460,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T00:00:00Z","timestamp":1579392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diffusion-weighted magnetic resonance imaging (DW-MRI) with apparent diffusion coefficient (ADC) measurement provides additional information about tumor microstructure with potential relevance for staging and predicting aggressive disease in patients with endometrial cancer (EC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine whether ADC values in EC diverge according to the tumor\u2019s histologic grade and myometrial invasion depth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      A sample of 48 pathologically confirmed cases of EC were reviewed retrospectively. The sample was distributed as follows: G1 (n\u2009=\u20099); G2 (n\u2009=\u200918); G3 (n\u2009=\u200921); with myometrial invasion &lt;50% (n\u2009=\u200931); and with myometrial invasion \u226550% (n\u2009=\u200917). DW images were performed at 3.0T with b factors of 0\u20131000\/mm\n                      <jats:sup>2<\/jats:sup>\n                      . The region of interest (ROI) was defined within the tumor with T1-weighted and T2-weighted imaging and copied manually to an ADC map. The tumor\u2019s grade and myometrial invasion\u2019s depth were determined by postoperative histopathological tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The means of ADC\n                      <jats:sub>min<\/jats:sub>\n                      and ADC\n                      <jats:sub>mean<\/jats:sub>\n                      values were significantly lower for patients with G2 and G3 endometrial tumors than G1. The same tendency was observed in myometrial invasion, as both ADC\n                      <jats:sub>min<\/jats:sub>\n                      and ADC\n                      <jats:sub>mean<\/jats:sub>\n                      values were lower for patients with deep than for those with superficial myometrial invasion. The cut-off values of the ADC\n                      <jats:sub>min<\/jats:sub>\n                      and ADC\n                      <jats:sub>mean<\/jats:sub>\n                      that predicted high-grade tumors were 0.69\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      \u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s and 0.82\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      \u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s, respectively, while those for myometrial infiltration were 0.70\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      \u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s (ADC\n                      <jats:sub>min<\/jats:sub>\n                      ) and 0.88\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      \u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s (ADC\n                      <jats:sub>mean<\/jats:sub>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      ADC\n                      <jats:sub>min<\/jats:sub>\n                      and ADC\n                      <jats:sub>mean<\/jats:sub>\n                      values correlated with histologic tumor grade and myometrial invasion depth; therefore, it is suggested that ADC on MRI may be a useful indicator to predict malignancy of ECs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185119898658","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T23:43:19Z","timestamp":1579477399000},"page":"1277-1286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["The apparent diffusion coefficient (ADC) on 3-T MRI differentiates myometrial invasion depth and histological grade in patients with endometrial cancer"],"prefix":"10.1177","volume":"61","author":[{"given":"Juan Armando","family":"Reyes-P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Radiology, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Villase\u00f1or-Navarro","sequence":"additional","affiliation":[{"name":"Department of Radiology, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Evelia","family":"Jim\u00e9nez de los Santos","sequence":"additional","affiliation":[{"name":"Department of Radiology, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irlanda","family":"Pacheco-Bravo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Calle-Loja","sequence":"additional","affiliation":[{"name":"Department of Radiology, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4569-3643","authenticated-orcid":false,"given":"Isabel","family":"Sollozo-Dupont","sequence":"additional","affiliation":[{"name":"Department of Radiology, Instituto Nacional de Cancerolog\u00eda, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,19]]},"reference":[{"key":"bibr1-0284185119898658","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082348"},{"key":"bibr2-0284185119898658","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001208"},{"key":"bibr3-0284185119898658","unstructured":"American Cancer Society. 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