{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:19:06Z","timestamp":1787498346301,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Climbing fund of the National Cancer Center of China","award":["NCC201806B011"],"award-info":[{"award-number":["NCC201806B011"]}]},{"name":"Support program of the youth science and technology innovation talents of Shenyang City","award":["RC180269"],"award-info":[{"award-number":["RC180269"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Computed tomography perfusion (CTP) can provide information on blood perfusion as a reliable marker of tumor response to therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the role of volume CTP (vCTP) parameters in predicting treatment response to concurrent chemoradiotherapy (CCRT) for cervical cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Thirty-three patients with cervical cancer underwent vCTP. Three CTP parameters of cervical cancer\u2014including arterial flow (AF), blood volume (BV), and permeability surface (PS)\u2014were measured in two different ways: the region of interest incorporating the \u201clocal hot\u201d with the highest enhancement and \u201ccold spot\u201d with the lowest enhancement; and \u201cwhole-tumor\u201d measurements. The patients were divided into non-residual and residual tumor groups according to the short-term response to treatment. The clinical and perfusion parameters were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no significant difference in age, body mass index, FIGO stage, pathological grade, or pretreatment tumor size between the two groups ( P\u2009&gt;\u20090.05). The non-residual tumor group had higher pretreatment AF in high-perfusion and low-perfusion subregions than the residual tumor group ( P\u2009&lt;0.05), but the AF in whole-tumor regions was not different between the two groups ( P\u2009&gt;\u20090.05). There were no differences in BV and PS between the two groups ( P\u2009&gt;\u20090.05). The diagnostic potency of AF in the low-perfusion subregion was higher than that in the high-perfusion subregion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>vCTP parameters are valuable for the prediction of short-term effects. The AF in the low-perfusion subregion was a more effective index for predicting treatment response to CCRT of cervical cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185120919261","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T02:27:03Z","timestamp":1592447223000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Volume computed tomography perfusion as a predictive marker for treatment response to concurrent chemoradiotherapy in cervical cancer: a prospective study"],"prefix":"10.1177","volume":"62","author":[{"given":"Tong","family":"Dong Rui","sequence":"first","affiliation":[{"name":"Department of Radiology, Cancer Hospital of China Medical University, LiaoNing Cancer Hospital & Institute, Shenyang, Liaoning, PR 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