{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:06:02Z","timestamp":1784631962520,"version":"3.55.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Imaging of colorectal cancer liver metastases (CRCLMs) has improved in recent years. Therefore, the role of current imaging techniques needs to be defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the diagnostic performance of contrast-enhanced ultrasound (CEUS), multidetector computed tomography (MDCT), magnetic resonance imaging (MRI), and fluorodeoxyglucose (FDG) positron emission tomography (PET)\/CT in the detection of CRCLMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>PubMed database was searched for articles published during 2000\u20132019. Inclusion criteria were as follows: diagnosis\/suspicion of CRCLMs; CEUS, MDCT, MRI, or FDG PET\/CT performed for the detection of CRCLMs; prospective study design; histopathologic examination, intraoperative findings and\/or follow-up used as reference standard; and data for calculating sensitivity and specificity reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve prospective studies were assessed, including 536 patients with CRCLMs (n\u2009=\u20091335). On a per-lesion basis, the sensitivity of CEUS, MDCT, MRI, and FDG PET\/CT was 86%, 84%, 89%, and 62%, respectively. MRI had the highest sensitivity on a per-lesion analysis. CEUS and MDCT had comparable sensitivities. On a per-patient basis, the sensitivity and specificity of CEUS, MDCT, MRI, and FDG PET\/CT was 80% and 97%, 87% and 95%, 87% and 94%, and 96% and 97%, respectively. The per-patient sensitivities for MRI and MDCT were similar. The sensitivity for MRI was higher than that for CEUS, MDCT, and FDG PET\/CT for lesions &lt;10\u2009mm and lesions at least 10\u2009mm in size. Hepatospecific contrast agent did not improve diagnostic performances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRI is the preferred imaging modality for evaluating CRCLMs. Both MDCT and CEUS can be used as alternatives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185120925481","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T13:01:06Z","timestamp":1591448466000},"page":"302-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":57,"title":["Imaging of colorectal cancer liver metastases using contrast-enhanced US, multidetector CT, MRI, and FDG PET\/CT: a meta-analysis"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2762-6268","authenticated-orcid":false,"given":"Athina C","family":"Tsili","sequence":"first","affiliation":[{"name":"Department of Clinical Radiology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Alexiou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Naka","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I","family":"Argyropoulou","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,6]]},"reference":[{"key":"bibr1-0284185120925481","unstructured":"American Cancer Society. 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