{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:34:53Z","timestamp":1788042893924,"version":"build-2784847793"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic valvular heart disease leads to systolic dysfunction and left atrial enlargement that ultimately results in heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate prognostic importance of Echocardiography and plasma natriuretic peptide levels that increase as a compensatory response and can be used as predictive markers for cardiac hypertrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>The patients were divided into three groups: 51 with left ventricle hypertrophy due to aortic valve disease; 126 with left atrial enlargement due to mitral valve dysfunction; and 76 with both conditions. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) plasma levels were measured in all three respective groups showing dilated cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean left ventricular end-diastolic dimension at 64.3\u2009\u00b1\u20091.6\u2009mm ( P\u2009&lt;\u20090.00) and left atrial dimension at 58.3\u2009\u00b1\u20093.7\u2009mm ( P\u2009&lt;\u20090.00) were significantly high. However, patients with both conditions showed significantly high values for left ventricular end-diastolic dimension (63.3\u2009\u00b1\u20093\u2009mm, P\u2009&lt;\u20090.00) and left atrial dimension (54.9\u2009\u00b1\u20094\u2009mm, P\u2009&lt;\u20090.00) when compared with controls. A significant positive correlation was found between plasma natriuretic peptides levels and dilated cardiomyopathy. The mean values of ANP were 173\u2009\u00b1\u200946.6\u2009pg\/mL ( P\u2009&lt;\u20090.00), 140.4\u2009\u00b1\u200942.4\u2009pg\/mL ( P\u2009&lt;\u20090.00), and 295.1\u2009\u00b1\u200967.5\u2009pg\/mL ( P\u2009&lt;\u20090.00), significantly high in all three respective disease groups. The levels of BNP were also significantly high at 189\u2009\u00b1\u200944.5\u2009pg\/mL ( P\u2009&lt;\u20090.00), 166.6\u2009\u00b1\u200936.6\u2009pg\/mL ( P\u2009&lt;\u20090.00), and 323\u2009\u00b1\u200969.1\u2009pg\/mL ( P\u2009&lt;\u20090.00) in the disease groups with left ventricular hypertrophy, left atrial enlargement, and the disease group showing both characteristics, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Significant positive associations were found between left ventricle hypertrophy and left atrial enlargement with ANP and BNP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185120933530","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T01:53:41Z","timestamp":1592877221000},"page":"603-609","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiac hypertrophic risk markers of left ventricle and left atrium in chronic heart failure due to aortic and mitral valve disease"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2770-3040","authenticated-orcid":false,"given":"Muhammad Ishtiaq","family":"Jan","sequence":"first","affiliation":[{"name":"Department of Chemistry, Kohat University of Science & Technology (KUST), Kohat, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riaz Anwar","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Lady Reading Hospital Peshawar, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeem","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Kohat University of Science & Technology (KUST), Kohat, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Mahak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Kohat University of Science & Technology (KUST), Kohat, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar Ul Haq Ali","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Kohat University of Science & Technology (KUST), Kohat, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Tasleem","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Kohat University of Science & Technology (KUST), Kohat, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahaq ullah","family":"Kakakhel","sequence":"additional","affiliation":[{"name":"Ministry of National Food Security and Research, Peshawar, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iram","family":"Murtaza","sequence":"additional","affiliation":[{"name":"Faculty of Biological Sciences, Department of Biochemistry, Quaid-I-Azam University, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"bibr1-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.202"},{"key":"bibr2-0284185120933530","first-page":"H65","volume":"275","author":"Matsuo T","year":"1998","journal-title":"Am J Physiol"},{"key":"bibr3-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.4.470"},{"key":"bibr4-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.029"},{"key":"bibr5-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.091688"},{"key":"bibr6-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.07.003"},{"key":"bibr7-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.06.066"},{"key":"bibr8-0284185120933530","first-page":"160","volume":"157","author":"Palazzuoli A","year":"2013","journal-title":"Scientific World Journal"},{"key":"bibr9-0284185120933530","doi-asserted-by":"crossref","unstructured":"Jan MI, Khan RA, Sultan A, et al. Analysis of nt-probnp and uric acid due to left ventricle hypertrophy in the patients of aortic valve disease. Pakistan J Med Sci 2019;35:183\u2013188.","DOI":"10.12669\/pjms.35.1.148"},{"key":"bibr10-0284185120933530","doi-asserted-by":"crossref","unstructured":"Jan MI, Khan RA, Ali T, et al. Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. Arch Biochem Biophys 2017;633:50\u201357.","DOI":"10.1016\/j.abb.2017.09.001"},{"key":"bibr11-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00047.2003"},{"key":"bibr12-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01370.x"},{"key":"bibr13-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcx031"},{"key":"bibr14-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804602"},{"key":"bibr15-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003644"},{"key":"bibr16-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"bibr17-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.4.872"},{"key":"bibr18-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.05582"},{"key":"bibr19-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.2.259"},{"key":"bibr20-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.4.929"},{"key":"bibr21-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.078857"},{"issue":"50","key":"bibr22-0284185120933530","volume":"14","author":"Dweck MR","year":"2012","journal-title":"J Cardiovasc Magn Reson"},{"key":"bibr23-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.5.763"},{"key":"bibr24-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)03034-1"},{"key":"bibr25-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.5.1724"},{"key":"bibr26-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)91434-8"},{"key":"bibr27-0284185120933530","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.5.1730"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185120933530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0284185120933530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185120933530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:26:20Z","timestamp":1777389980000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0284185120933530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/0284185120933530"],"URL":"https:\/\/doi.org\/10.1177\/0284185120933530","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,22]]}}}