{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:48:26Z","timestamp":1777506506867,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Detection of breast cancer in women with high breast densities is a clinical challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To study the influence of different degrees of breast density on the sensitivity of contrast-enhanced breast magnetic resonance imaging (CE-BMRI) versus X-ray mammography (XRM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We performed an additional analysis of two large Phase III clinical trials (G1; G2) which included women with histologically proven breast cancers, called \u201cindex cancers.\u201d Additional cancers were detected during image reading. We compared the sensitivity of CE-BMRI and XRM in women with different breast densities (ACR A\u2192D; Version 5). For each study, six blinded readers evaluated the images. Results are given as the \u201cMedian Reader.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 774 patients were included, 169 had additional cancers. While sensitivity of CE-BMRI for detecting all index cancers was independent of breast density (ACR A\u2192D) (G1: 83%\u219283%; G2: 91%\u219291%) the sensitivity of XRM declined (ACR A\u2192D) (G1: 79%\u219262%; G2: 82%\u219264%). Thus, the sensitivity difference between both imaging modalities in ACR A breasts of 3% (G1) and 9% (G2) increased to 21% (G1) and 26% (G2) in ACR D breasts. Sensitivity of CE-BMRI for detecting at least one additional cancer increased with increasing breast density (ACR A\u2192D) (G1: 50%\u219273%, G2: 57%\u219281%). XRM\u2019s sensitivity decreased (G1: 34%\u219220%) or remained stable (G2: 24%\u219225%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CE-BMRI showed significantly higher sensitivity compared to XRM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185120936271","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T12:04:25Z","timestamp":1594987465000},"page":"586-593","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic efficacy of contrast-enhanced breast MRI versus X-ray mammography in women with different degrees of breast density"],"prefix":"10.1177","volume":"62","author":[{"given":"J\u00f6rg","family":"Barkhausen","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpad","family":"Bischof","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, University Hospital Schleswig Holstein, Luebeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Haverstock","sequence":"additional","affiliation":[{"name":"Bayer HealthCare Pharmaceuticals Inc, Whippany, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Klemens","sequence":"additional","affiliation":[{"name":"Bayer AG, General Clinical Imaging Services, 13353, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenther","family":"Brueggenwerth","sequence":"additional","affiliation":[{"name":"Bayer AG, General Clinical Imaging Services, 13353, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Weber","sequence":"additional","affiliation":[{"name":"Bayer AG, Radiology R&D, Berlin, Germany"},{"name":"Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-5014","authenticated-orcid":false,"given":"Jan","family":"Endrikat","sequence":"additional","affiliation":[{"name":"Bayer AG, Radiology R&D, Berlin, Germany"},{"name":"University Medical School of Saarland, Dept of Gynecology, Obstetrics and Reproductive Medicine, Homburg\/Saar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"bibr1-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2019.05.008"},{"key":"bibr2-0284185120936271","doi-asserted-by":"publisher","DOI":"10.7326\/M18-1822"},{"key":"bibr3-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-019-00992-1"},{"key":"bibr4-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000039"},{"key":"bibr5-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016161444"},{"key":"bibr6-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000254"},{"key":"bibr7-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26654"},{"key":"bibr8-0284185120936271","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13636"},{"key":"bibr9-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.2108"},{"key":"bibr10-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.11.035"},{"key":"bibr11-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21406"},{"key":"bibr12-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2017.11.034"},{"key":"bibr13-0284185120936271","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.02.015"},{"key":"bibr14-0284185120936271","unstructured":"ACR Practice Parameter for the Performance of Contrast Enhanced Magnetic Resonance Imaging (MRI) of the Breast. 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