{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:48:50Z","timestamp":1777506530186,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Abbreviated magnetic resonance imaging (aMRI) protocols have emerged as an alternative to multiparametric MRI (mpMRI) to reduce examination time and costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare multiple aMRI protocols for predicting pathological stage \u2265T3 (\u2265pT3) prostate cancer (PCa).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>One hundred and eight men undergoing staging mpMRI before radical prostatectomy (RP) were retrospectively evaluated. 3.0-T imaging was performed with a 32-channel surface coil and a protocol including diffusion-weighted imaging (DWI), transverse T2-weighted (tT2W) imaging, coronal T2W (cT2W) imaging, sagittal T2W (sT2) imaging, and dynamic contrast-enhanced (DCE) imaging. Two readers independently assessed whether any MRI observation showed stage \u2265T3 on each sequence (reading order: DWI, cT2W, tT2W, sT2W, DCE). Final stage was assessed by matching readers\u2019 assignments to pathology, and combining them into eight protocols: DWI\u2009+\u2009tT2W, DWI\u2009+\u2009cT2W\u2009+\u2009tT2W, DWI\u2009+\u2009tT2W\u2009+\u2009sT2W, DWI\u2009+\u2009cT2W\u2009+\u2009tT2W\u2009+\u2009sT2W, DWI\u2009+\u2009tT2W\u2009+\u2009DCE, DWI\u2009+\u2009cT2W\u2009+\u2009tT2W\u2009+\u2009DCE, DWI\u2009+\u2009tT2W\u2009+\u2009sT2W\u2009+\u2009DCE, and mpMRI. Diagnostic accuracy and inter-reader agreement for aMRI protocols were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prevalence of \u2265pT3 PCa was 31.5%. Sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of aMRI protocols were comparable to mpMRI for R1. Sensitivity was 74.3% (95% confidence interval [CI] 64.8\u201372.0) to 77.1% (95% CI 67.9\u201384.4), and NPV 86.8% (95% CI 78.6\u201392.3) to 88.1% (95% CI 80.1\u201393.3). All accuracy measures of the various aMRI protocols were similar to mpMRI also for R2, albeit all slightly lower compared to R1. On a per-protocol basis, there was substantial inter-reader agreement in predicting stage \u2265pT3 (k 0.63\u20130.67).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When comparing the diagnostic accuracy of multiple aMRI protocols against mpMRI for predicting stage \u2265pT3 PCa, the protocol with the fewest sequences (DWI\u2009+\u2009tT2W) is apparently equivalent to standard mpMRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185120943047","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T01:45:03Z","timestamp":1595900703000},"page":"949-958","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Accuracy of abbreviated multiparametric MRI-derived protocols in predicting local staging of prostate cancer in men undergoing radical prostatectomy"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6995-246X","authenticated-orcid":false,"given":"Gianluca","family":"Giannarini","sequence":"first","affiliation":[{"name":"Urology Unit, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Cereser","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Como","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Bonato","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Udine, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Pizzolitto","sequence":"additional","affiliation":[{"name":"Pathology Unit, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Valotto","sequence":"additional","affiliation":[{"name":"Urology Unit, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Ficarra","sequence":"additional","affiliation":[{"name":"Department of Human and Pediatric Pathology \u201cGaetano Barresi,\u201d Urologic Section, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Dal Moro","sequence":"additional","affiliation":[{"name":"Urologic Clinic, University of Udine, Udine, Italy"},{"name":"Department of Surgery, Oncology and Gastroenterology, Urology Unit, University of Padua, Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Zuiani","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"},{"name":"Department of Medicine, University of Udine, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossano","family":"Girometti","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"},{"name":"Department of Medicine, University of Udine, Academic Medical Centre \u201cSanta Maria della Misericordia,\u201d Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"bibr1-0284185120943047","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-016-0466-9"},{"key":"bibr2-0284185120943047","unstructured":"EAU \u2013 EANM \u2013 ESTRO \u2013 ESUR \u2013 SIOG Guidelines on Prostate Cancer. 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