{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:48:49Z","timestamp":1777506529306,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Finland State Research Funding"},{"name":"Turku University Hospital Medical Funds"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical utility of positron emission tomography\/magnetic resonance imaging (PET\/MRI) in comparison to standard work-up with patients with known or suspected inflammatory bowel disease (IBD) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the value of 18F-fluorodeoxyglucose (18F-FDG) PET\/MRI in the diagnostics of IBD and further compare the data obtained using PET\/MRI to histological findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Ten patients with relapse in IBD or with symptoms of suspected IBD were recruited either from a gastroenterology outpatient clinic or from a hospital ward. Intestinal inflammation was assessed with histology and 18F-FDG PET\/MRI. Maximum standard uptake values (SUV\n                      <jats:sub>max<\/jats:sub>\n                      ) were calculated in six regions of the intestine (small bowel, ascending, transverse, descending and sigmoid colon, and rectum) and compared to histological analysis of inflammation activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study showed that both the inflammation activity ( P\u2009=\u20090.008) and the region of the biopsy in the intestine ( P\u2009=\u20090.015) had a significant effect on SUV. SUVs obtained from severe inflammation activity emerged significantly from the background ( P\u2009=\u20090.006). In addition, the SUVs obtained from moderate inflammation raised from background, but the difference was not statistically significant ( P\u2009=\u20090.083), while SUVs of mild inflammation were at the same level with SUVs of normal bowel wall ( P\u2009=\u20090.988).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>18F-FDG PET\/MRI is a promising method of detecting especially severe inflammatory bowel lesions. More data are required to define its sensitivity and specificity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185120944900","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:35:08Z","timestamp":1595982908000},"page":"851-857","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The value of combined positron emission tomography\/magnetic resonance imaging to diagnose inflammatory bowel disease: a prospective study"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2977-5446","authenticated-orcid":false,"given":"Mervi","family":"Tenhami","sequence":"first","affiliation":[{"name":"Division of Digestive Surgery, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Turku University Hospital, Turku, Finland; Medical Imaging Centre of Southwest Finland, University of Turku, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saila","family":"Kauhanen","sequence":"additional","affiliation":[{"name":"Division of Digestive Surgery, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Koffert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Kemppainen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine and Turku PET Centre, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virva","family":"Saunavaara","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Turku PET 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