{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:59:07Z","timestamp":1777931947821,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260232"],"award-info":[{"award-number":["81260232"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Qinghai Science & Technology Department","award":["2017-SF-158"],"award-info":[{"award-number":["2017-SF-158"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KA 4356\/3-1"],"award-info":[{"award-number":["KA 4356\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KR 5204\/1-2"],"award-info":[{"award-number":["KR 5204\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The main endemic areas of alveolar echinococcosis (AE) are in central Europe and western China. The infiltration of intrahepatic vascular and bile ducts as well as extrahepatic disease can lead to complications and may increase morbidity in AE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the vascular\/biliary involvement of hepatic alveolar echinococcosis (HAE) and distant extrahepatic disease at each of four locations in Germany, France, and China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Contrast-enhanced abdominal magnetic resonance imaging (MRI) scans of patients with HAE, 200 in total, were evaluated by five examiners. AE liver lesions were classified according to Kodama\u2019s classification. Furthermore, distant extrahepatic manifestations were documented with additionally performed imaging modalities. Vascular\/biliary involvement of hepatic manifestations as well as the presence of extrahepatic manifestations were correlated with the respective Kodama type of the liver lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Distant extrahepatic AE manifestations were significantly more frequent in China than in Europe (12\/100 vs. 3\/100; Fisher\u2019s exact test: P=0.0286). A significant relationship exists between presence of distant extrahepatic disease manifestation and size of the AE liver lesion (132.53\u2009\u00b1\u200948.65 vs. 92.49\u2009\u00b1\u200950.06; P\u2009=\u20090.0030). Vascular\/biliary involvement is significantly more frequent in China than in Europe (86\/100 vs. 65\/100; \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200911.92; P\u2009=\u20090.0006). Vascular\/biliary involvement depends on lesion size (111.10\u2009\u00b1\u200947.44 vs. 47.36\u2009\u00b1\u200924.36; P&lt;0.0001). Different types of AE liver lesions are associated with differences in vascular\/biliary involvement and extrahepatic manifestations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vascular\/biliary involvement and presence of distant extrahepatic manifestations depend on size of the HAE lesions and are more frequently detected in China. Different MRI morphological patterns influence vascular\/biliary involvement and the occurrence of distant extrahepatic manifestations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185120951958","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T01:18:01Z","timestamp":1598491081000},"page":"997-1005","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis: a multicenter cohort study"],"prefix":"10.1177","volume":"62","author":[{"given":"Tilmann","family":"Graeter","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haihua","family":"Bao","sequence":"additional","affiliation":[{"name":"Qinghai University, Qinghai University First Affiliated Hospital, Qinghai Province, Xining, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenya","family":"Liu","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University, First Affiliated Hospital, WHO Collaborating Centre on Prevention and Care Management of Echinococcosis, Urumqi, Xinjiang Uyghur Autonomous Region, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixia","family":"Li","sequence":"additional","affiliation":[{"name":"Qinghai University, Qinghai University First Affiliated Hospital, Qinghai Province, Xining, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University, First Affiliated Hospital, WHO Collaborating Centre on Prevention and Care Management of Echinococcosis, Urumqi, Xinjiang Uyghur Autonomous Region, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Schmidberger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonore","family":"Brumpt","sequence":"additional","affiliation":[{"name":"University of Franche-Comt\u00e9, WHO Collaborating Centre\/National French Reference Centre for Echinococcosis, Besan\u00e7on, France"},{"name":"Department of Radiology, Besan\u00e7on University Hospital, Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Delabrousse","sequence":"additional","affiliation":[{"name":"University of Franche-Comt\u00e9, WHO Collaborating Centre\/National French Reference Centre for Echinococcosis, Besan\u00e7on, France"},{"name":"Department of Radiology, Besan\u00e7on University Hospital, Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9727-3843","authenticated-orcid":false,"given":"Wolfgang","family":"Kratzer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the XUUB consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"bibr1-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apar.2016.09.006"},{"key":"bibr2-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.11.001"},{"key":"bibr3-0284185120951958","doi-asserted-by":"crossref","unstructured":"Baumann S, Shi R, Liu W, et al. Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century. Infection 2019;47:703\u2013727.","DOI":"10.1007\/s15010-019-01325-2"},{"key":"bibr4-0284185120951958","doi-asserted-by":"crossref","unstructured":"Kratzer W, Gruener B, Kaltenbach TE, et al. Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound. World J Gastroenterol 2015;21:12392\u201312402.","DOI":"10.3748\/wjg.v21.i43.12392"},{"key":"bibr5-0284185120951958","doi-asserted-by":"crossref","unstructured":"Graeter T, Kratzer W, Oeztuerk S, et al. Proposal of a computed tomography classification for hepatic alveolar echinococcosis. World J Gastroenterol 2016;22:3621\u20133631.","DOI":"10.3748\/wjg.v22.i13.3621"},{"key":"bibr6-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2281020323"},{"key":"bibr7-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0183-0"},{"key":"bibr8-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-011-0205-6"},{"key":"bibr9-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-001-1081-2"},{"key":"bibr10-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20078"},{"key":"bibr11-0284185120951958","doi-asserted-by":"crossref","unstructured":"Graeter T, Ehing F, Oeztuerk S, et al. Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study. World J Gastroenterol 2015;21:4925\u20134932.","DOI":"10.3748\/wjg.v21.i16.4925"},{"key":"bibr12-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1007\/s150100050079"},{"key":"bibr13-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2017.1252260"},{"key":"bibr14-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004278"},{"key":"bibr15-0284185120951958","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i19.5881"},{"key":"bibr16-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05877.x"},{"key":"bibr17-0284185120951958","first-page":"160","volume":"39","author":"Sezgin O","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"bibr18-0284185120951958","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2013.51.4.475"},{"key":"bibr19-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.5.762"},{"key":"bibr20-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.22.2503"},{"key":"bibr21-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2008.00892.x"},{"key":"bibr22-0284185120951958","first-page":"11192","volume":"8","author":"Wang H","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr23-0284185120951958","first-page":"369","volume":"71","author":"Matsuhisa T.","year":"1996","journal-title":"Hokkaido Igaku Zasshi"},{"key":"bibr24-0284185120951958","first-page":"444","volume":"32","author":"Kunze V","year":"1992","journal-title":"Radiologe"},{"key":"bibr25-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927423"},{"key":"bibr26-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927424"},{"key":"bibr27-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.12.025"},{"key":"bibr28-0284185120951958","doi-asserted-by":"crossref","unstructured":"Hillenbrand A, Beck A, Kratzer W, et al. Impact of affected lymph nodes on long-term outcome after surgical therapy of alveolar echinococcosis. Langenbecks Arch Surg 2018;403:655\u2013662.","DOI":"10.1007\/s00423-018-1687-9"},{"key":"bibr29-0284185120951958","first-page":"470","volume":"111","author":"Jiang C.","year":"1998","journal-title":"Chin Med J (Engl)"},{"key":"bibr30-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1592122"},{"key":"bibr31-0284185120951958","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.76281"},{"key":"bibr32-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2011.07.005"},{"key":"bibr33-0284185120951958","doi-asserted-by":"publisher","DOI":"10.1080\/02841850902878161"},{"key":"bibr34-0284185120951958","first-page":"4197","volume":"17","author":"Yang X","year":"2019","journal-title":"Exp Ther Med"},{"key":"bibr35-0284185120951958","doi-asserted-by":"crossref","unstructured":"Gr\u00e4ter T, Bao H, Delabrousse E, et al. Hepatic alveolar echinococcosis: comparative computed tomography study between two Chinese and two European centres. Food Waterborne Parasitol. 2020. DOI: https:\/\/doi.org\/10.1016\/j.fawpar.2020.e00082.","DOI":"10.1016\/j.fawpar.2020.e00082"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185120951958","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0284185120951958","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185120951958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:26:32Z","timestamp":1777389992000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0284185120951958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,26]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1177\/0284185120951958"],"URL":"https:\/\/doi.org\/10.1177\/0284185120951958","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,26]]}}}