{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:39:53Z","timestamp":1790073593330,"version":"4.0.1"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Positron emission tomography (PET) findings for gliomatosis and lymphomatosis have been rarely reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To compare PET\/computed tomography (CT) findings using\n                      <jats:sup>11<\/jats:sup>\n                      C-methionine (MET) from PET\/CT findings using\n                      <jats:sup>18<\/jats:sup>\n                      F-fluorodeoxy glucose (FDG) for patients with lymphomatosis or gliomatosis of the brain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Participants comprised all 10 patients with lymphomatosis or gliomatosis of the brain treated at our institution in the past 12 years. Underlying pathologies comprised intravascular lymphoma (n\u2009=\u20091), lymphomatosis (n\u2009=\u20093), and gliomatosis (n\u2009=\u20096). All cases were pathologically diagnosed. In seven patients, both MET-PET\/CT and FDG-PET\/CT were performed simultaneously in a single study. In three patients, only FDG-PET\/CT was performed. The degree of tracer accumulation to the lesion was evaluated qualitatively. Quantitatively, the ratio of maximum standard uptake value (SUV\n                      <jats:sub>max<\/jats:sub>\n                      ) in tumor to that in normal tissue (T\/N ratio) was measured and compared between FDG and MET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Qualitatively, MET accumulated to part of the lesion in six of seven patients and almost all of the lesion in one in seven patients. FDG accumulated to part of the lesion in three of ten patients and almost all of the lesion in one of ten patients. No FDG accumulation was seen in the lesion in six patients. Quantitatively, mean\u2009\u00b1\u2009SD T\/N ratio was significantly higher with MET (2.11\u2009\u00b1\u20090.63) than with FDG (1.18\u2009\u00b1\u20090.84; P\u2009&lt;\u20090.05, Wilcoxon signed-rank test).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In lymphomatosis and gliomatosis, FDG accumulates in only part of the lesion. FDG is thus less suitable than MET for depicting these lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185120966710","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T01:23:09Z","timestamp":1603243389000},"page":"1391-1396","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["PET findings in lymphomatosis and gliomatosis of the brain: a comparison of C-11 methionine  PET\/CT and F-18 FDG PET\/CT"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-0410","authenticated-orcid":false,"given":"Noriaki","family":"Tomura","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Saginoya","sequence":"additional","affiliation":[{"name":"Department of Radiology, Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama City, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"bibr1-0284185120966710","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12432"},{"key":"bibr2-0284185120966710","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov197"},{"key":"bibr3-0284185120966710","doi-asserted-by":"publisher","DOI":"10.1159\/000492465"},{"key":"bibr4-0284185120966710","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00165"},{"key":"bibr5-0284185120966710","doi-asserted-by":"crossref","unstructured":"Tomura N, Ito Y, Matsuoka H, et al. PET findings of intramedullary tumors of the spinal cord using [18F] FDG and [11C] methionine. 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PET\/CT findings for tumors in the base of the skull: comparison of\n                      18\n                      F-FDG with 11C-methionine. Acta Radiol 2016;57:325\u2013332.","DOI":"10.1177\/0284185115575342"},{"key":"bibr27-0284185120966710","doi-asserted-by":"crossref","unstructured":"Tomura N, Saginoya T, Goto H. 11C-methionine positron emission tomography \/ computed tomography versus\n                      18\n                      F-fluorodeoxyglucose positron emission tomography \/ computed tomography in evaluation of residual or recurrent World Health organization grades II and III meningioma after treatment. 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