{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:27:16Z","timestamp":1790465236320,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High-grade pineal region tumors are rare and heterogeneous types of primary central nervous system neoplasms; radiological differential diagnosis is challenging but it is important because it has a therapeutic relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To discriminate among high-grade pineal region tumors by combining apparent diffusion coefficient (ADC) volumetric values and qualitative features in order to predict their histology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Twenty-two patients with high-grade pineal region tumors were assessed by qualitative and quantitative analysis. Margins, T2-weighted signal intensity, contrast enhancement, hemorrhage, calcifications, different volumetric ADC fractions (ADC\n                      <jats:sub>mean<\/jats:sub>\n                      , ADC\n                      <jats:sub>max<\/jats:sub>\n                      , ADC\n                      <jats:sub>min<\/jats:sub>\n                      ) were evaluated and were compared to the histopathologic findings (cell count and proliferation index).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our qualitative imaging data showed that only margins were different among different tumors and each tumor type showed peculiar age onset. ADC\n                      <jats:sub>mean<\/jats:sub>\n                      was found the best quantitative value to discriminate high-grade tumors of the pineal region. ADC\n                      <jats:sub>mean<\/jats:sub>\n                      correlated with proliferation index but not with cell count. ADC\n                      <jats:sub>mean<\/jats:sub>\n                      values were lower in tumors with higher proliferation rate and a significant difference in ADC\n                      <jats:sub>mean<\/jats:sub>\n                      values were found between germinomas and pineoblastomas, between germinomas and papillary tumors and between papillary tumors and pineoblastomas. Moreover, the cut-off value of 0.865\u2009\u00d7\u200910\n                      <jats:sup>\u20133<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s for ADC\n                      <jats:sub>mean<\/jats:sub>\n                      (ADC mean threshold value) could differentiate germinoma from pineoblastomas with the best combination of sensitivity and specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The ADC\n                      <jats:sub>mean<\/jats:sub>\n                      value measured on the whole tumor, reflecting tumor proliferative activity, may be a practical and non-invasive marker for predicting tumor histology in high-grade pineal region lesions and might be useful in preoperative assessment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0284185120986912","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T12:58:40Z","timestamp":1611665920000},"page":"222-231","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of high-grade pineal region lesions: the usefulness of apparent diffusion coefficient volumetric values"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4517-3477","authenticated-orcid":false,"given":"Rosalinda","family":"Calandrelli","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma-UOC Radiologia e Neuroradiologia, Polo Diagnostica per immagini, radioterapia, oncologia ed ematologia, Area diagnostica per immagini, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pilato","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma-UOC Neurologia - Polo scienze dell\u2019invecchiamento, neurologiche, ortopediche e della testa-collo, Area Neuroscienze, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Massimi","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma-UOC Neurochirurgia Infantile - Polo scienze dell\u2019invecchiamento, neurologiche, ortopediche e della testa-collo, Area Neuroscienze, Rome, Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore, Istituto di Neurochirurgia, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gessi","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma-UOC Anatomia Patologica- UOS Neuropatologia, Rome, Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore, Istituto di Anatomia Patologica, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Panfili","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma-UOC Radiologia e Neuroradiologia, Polo Diagnostica per immagini, radioterapia, oncologia ed ematologia, Area diagnostica per immagini, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Colosimo","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma-UOC Radiologia e Neuroradiologia, Polo Diagnostica per immagini, radioterapia, oncologia ed ematologia, Area diagnostica per immagini, Rome, Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore, Istituto di Radiologia, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"bibr1-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-008-0126-8"},{"key":"bibr2-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181f895a4"},{"key":"bibr3-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(03)00080-6"},{"key":"bibr4-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00389-2"},{"key":"bibr5-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1177\/1971400915581741"},{"key":"bibr6-0284185120986912","first-page":"e585","volume":"8","author":"Wong K","year":"2016","journal-title":"Cureus"},{"key":"bibr7-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00242.x"},{"key":"bibr8-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1177\/1051228405001514"},{"key":"bibr9-0284185120986912","first-page":"3807","volume":"37","author":"Surov A","year":"2017","journal-title":"Anticancer Res"},{"key":"bibr10-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.11.021"},{"key":"bibr11-0284185120986912","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20406"},{"key":"bibr12-0284185120986912","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2806"},{"key":"bibr13-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1334-2"},{"key":"bibr14-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-017-2513-x"},{"key":"bibr15-0284185120986912","first-page":"1538","volume":"25","author":"Hayashida Y","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr16-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-013-0248-6"},{"key":"bibr17-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161386"},{"key":"bibr18-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2019.07.004"},{"key":"bibr19-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"bibr20-0284185120986912","unstructured":"Nakazato Y. [The 4th Edition of WHO Classification of Tumours of the Central Nervous System published in 2007]. No Shinkei Geka 2008; 36:473\u2013491."},{"key":"bibr21-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1148\/rg.307105131"},{"key":"bibr22-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.087460"},{"key":"bibr23-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2012.01.039"},{"key":"bibr24-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2008000100015"},{"key":"bibr25-0284185120986912","first-page":"6841","volume":"35","author":"Surov A","year":"2015","journal-title":"Anticancer Res"},{"key":"bibr26-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2353031338"},{"key":"bibr27-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199901)9:1<53::AID-JMRI7>3.0.CO;2-2"},{"key":"bibr28-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2241010637"},{"key":"bibr29-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-9970-9"},{"key":"bibr30-0284185120986912","first-page":"641","volume":"22","author":"Matsumoto Y","year":"2009","journal-title":"Oncol Rep"},{"key":"bibr31-0284185120986912","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.1403"},{"key":"bibr32-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25203"},{"key":"bibr33-0284185120986912","volume":"10","author":"Gihr GA","journal-title":"Front Oncol 2020"},{"key":"bibr34-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2018.05.009"},{"key":"bibr35-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2016.09.001"},{"key":"bibr36-0284185120986912","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200270"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185120986912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0284185120986912","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0284185120986912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:26:50Z","timestamp":1777390010000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0284185120986912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1177\/0284185120986912"],"URL":"https:\/\/doi.org\/10.1177\/0284185120986912","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,26]]}}}