{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:24:36Z","timestamp":1781889876047,"version":"3.54.5"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with hepatic metastatic uveal melanoma still have a poor outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate overall survival (OS), progression-free survival (PFS), and response predictors in these patients treated with chemosaturation by percutaneous hepatic perfusion with melphalan (CS-PHP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Between June 2015 and March 2020, a total of 29 patients (median age 69.7 years; age range 30\u201381 years; 60% women; median BMI 25.7 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; range 18.7\u201335.3kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; 1\u20136 procedures per patient) were treated with 53 CS-PHPs. All patients received cross-sectional imaging for initial and follow-up examinations. Baseline tumor load, extrahepatic tumor load, tumor response, PFS, and OS were assessed. Non-parametric statistics were used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After the initial CS-PHP, a partial response was observed in 11 patients (41%), stable disease in 12 patients (44%) and progressive disease in 4 patients (15%); two patients died before the response was evaluated. After initial CS-PHP, median OS was 12.9\u2009\u00b1\u20097.4 months and median PFS was 7.1\u2009\u00b1\u20097.4 months. OS after one year was 50%. After the second CS-PHP, median PFS was 7.9\u2009\u00b1\u20095.7 months. Seven patients had a liver tumor burden &gt;25%, associated with a significantly shorter OS (6.0\u2009\u00b1\u20092.4 vs. 14.1\u2009\u00b1\u200912.7 months; P\u2009=\u20090.008). At the time of first CS-PHP, 41% (12\/29) of the patients had extrahepatic metastases that did not affect OS (11.1\u2009\u00b1\u20098.4 months vs. 12.9\u2009\u00b1\u200913.6 months; P\u2009=\u20090.66).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CS-PHP is a safe and effective treatment for the hepatic metastatic uveal melanoma, especially for patients with a hepatic tumor burden &lt;25%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851211019808","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T01:39:30Z","timestamp":1621993170000},"page":"577-585","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and tolerability of chemosaturation in patients with hepatic metastases from uveal melanoma"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-7497","authenticated-orcid":false,"given":"Arne","family":"Estler","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Artzner","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bitzer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Gastrointestinal Oncology, Hepatology and Infectious Diseases, Eberhard Karls University, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1383-4798","authenticated-orcid":false,"given":"R\u00fcdiger","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hepp","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-9428","authenticated-orcid":false,"given":"Florian","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eigentler","sequence":"additional","affiliation":[{"name":"Center for Dermatooncology, Department of Dermatology, Eberhard Karls University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Forschner","sequence":"additional","affiliation":[{"name":"Center for Dermatooncology, Department of Dermatology, Eberhard Karls University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Gr\u00f6zinger","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"bibr1-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.040"},{"key":"bibr2-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0538"},{"key":"bibr3-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1177\/1758834018757175"},{"key":"bibr4-02841851211019808","author":"Diener-West M","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"bibr5-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0522"},{"key":"bibr6-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.9567"},{"issue":"15","key":"bibr7-02841851211019808","author":"Willson JKV","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"bibr8-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28480"},{"key":"bibr9-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2018.04.030"},{"key":"bibr10-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2014.11.037"},{"key":"bibr11-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1465587"},{"key":"bibr12-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-006-0155-z"},{"key":"bibr13-02841851211019808","author":"Vogl TJ","year":"2014","journal-title":"RoFo"},{"key":"bibr14-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-017-1588-2"},{"key":"bibr15-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23501"},{"key":"bibr16-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4968-3"},{"key":"bibr17-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-019-0218-4"},{"key":"bibr18-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1177\/1073274820983019"},{"key":"bibr19-02841851211019808","author":"de Leede EM","year":"2017","journal-title":"Cardiovasc Intervent Radiol"},{"key":"bibr20-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-013-0826-5"},{"key":"bibr21-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30258"},{"key":"bibr22-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.9511"},{"key":"bibr23-02841851211019808","unstructured":"Nielsen D. Immunocore\u2019s tebentafusp demonstrates superior overall survival compared to investigator\u2019s choice in a Phase 3 clinical trial of patients with previously untreated metastatic uveal melanoma. Oxford: Immunocore, 2020 Available at: https:\/\/www.immunocore.com\/news\/immunocores-tebentafusp-demonstrates-superior-overall-survival-compared-investigators-choice-phase-3-clinical-trial-patients-pre."},{"key":"bibr24-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-019-02177-x"},{"key":"bibr25-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190199"},{"key":"bibr26-02841851211019808","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.230870"},{"key":"bibr27-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000356"},{"key":"bibr28-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.03.064"},{"key":"bibr29-02841851211019808","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24956"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851211019808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02841851211019808","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851211019808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:27:03Z","timestamp":1777390023000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02841851211019808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1177\/02841851211019808"],"URL":"https:\/\/doi.org\/10.1177\/02841851211019808","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]}}}