{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:55:01Z","timestamp":1777506901428,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Grant No. GINOP","award":["2.1.1-15-2015-00609."],"award-info":[{"award-number":["2.1.1-15-2015-00609."]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sensitive imaging modalities in the diagnosis of microcircular complications of the lower extremities induced by metabolic diseases are becoming a focus of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To investigate the [\n                      <jats:sup>99m<\/jats:sup>\n                      Tc]HMPAO uptake of the legs in type 2 diabetes mellitus (T2DM) and obesity, and to search for associations with clinical parameters and nerve conducting studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 57 patients with controlled T2DM and 46 obese participants without DM were enrolled in the study. [\n                      <jats:sup>99m<\/jats:sup>\n                      Tc]HMPAO SPECT\/CT examinations were performed to evaluate the radiopharmaceutical accumulation of the legs. For the quantitative assessment of tracer uptake, standardized uptake value (SUV\n                      <jats:sub>peak<\/jats:sub>\n                      ) was measured in fixed spheric volumes of interest placed on both sural muscles on the attenuation-corrected images. Measurement of current perception threshold applying Neurometer (NM-01\/CPT) was used to evaluate peripheral nerve dysfunction. Laboratory parameters assessing the glucose homeostasis of the study participants were also measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the diabetic group, significantly lower leg SUV values were detected compared to the non-DM obese group (median: 0.517 vs. 0.607; P\u2009&lt;\u20090.001). Body mass index (BMI) ( P\u2009&lt;\u20090.0001), age ( P\u2009=\u20090.0283), HbA1c ( P\u2009=\u20090.0068), and glucose level ( P\u2009=\u20090.0044) proved to be significant predictors of muscle tracer uptake. Neurometer studies showed positive correlation with HbA1c levels in the T2DM group ( P\u2009=\u20090.0002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We assume that [\n                      <jats:sup>99m<\/jats:sup>\n                      Tc]HMPAO uptake of leg muscles is associated with microcirculation, so quantitative [\n                      <jats:sup>99m<\/jats:sup>\n                      Tc]HMPAO SPECT\/CT might be a sensitive method for evaluating lower limb microvascular alterations. BMI, age, HbA1c, and glucose level may be significant predictors of peripheral vascular abnormalities triggered by metabolic disturbances.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851211063601","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T07:01:58Z","timestamp":1639378918000},"page":"187-194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Imaging with [\n                    <sup>99m<\/sup>\n                    Tc]HMPAO \u2013 a novel perspective: investigation of [\n                    <sup>99m<\/sup>\n                    Tc]HMPAO leg muscle uptake in metabolic diseases"],"prefix":"10.1177","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-8521","authenticated-orcid":false,"given":"Zita","family":"K\u00e9pes","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, Division of 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