{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:25:04Z","timestamp":1790958304440,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few reports have examined the feasibility of a post-contrast double inversion recovery (DIR) magnetic resonance (MR) sequence in patients with multiple sclerosis (MS) because of partial or complete signal loss of enhancing MS lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare subtracted images of DIR (pre-contrast \u2013 post-contrast DIR images) with contrast enhanced T1-weighted (CE-T1W) images in the depiction of contrast enhancement of MS lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In total, 27 patients were included. Two neuroradiologists interpreted both images of CE-T1W imaging and subtracted DIR, and interpretation of the images was classified into a score of 1\u20135 (from 5, definitely superior contrast of lesions on DIR subtraction compared to conventional CE-T1W imaging, to 1, definitely superior contrast of lesions on CE-T1W imaging. The interrater agreement (\u03ba coefficient) was measured. The signal-to-noise ratio (SNR) and contrast-noise-ratio (CNR) of the lesion were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant difference ( P\u2009&lt; \u20090.001) in scoring was seen between conventional CE-T1W imaging (2.1\u2009\u00b1\u20091.5 with one reviewer and 2.4\u2009\u00b1\u20091.5 with the other) and DIR subtraction (4.4\u2009\u00b1\u20091.0 with one reviewer and 4.7\u2009\u00b1\u20090.8 with the other). SNR from conventional CE-T1W imaging (24.8\u2009\u00b1\u200914.7) was significantly superior to that from DIR subtraction (4.0\u2009\u00b1\u20091.0; P\u2009&lt; \u20090.001). CNR in DIR subtraction (326.4\u2009\u00b1\u2009250.0) was significantly superior to that in conventional CE-T1W imaging (0.8\u2009\u00b1\u20095.5; P\u2009&lt; \u20090.001). For interrater agreement in the evaluation of contrast enhancement of the lesions, \u03ba coefficients were 0.84 for conventional CE-T1W imaging and 0.72 for DIR subtraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Subtracted DIR image enables more obvious contrast enhancement of the MS lesions compared with conventional CE-T1W imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851221080831","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T03:49:18Z","timestamp":1647834558000},"page":"719-724","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Contrast-enhanced double inversion recovery sequence for patients with multiple sclerosis: feasibility of subtraction images between pre- and post-contrast 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Radiology and Neurology, Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama, Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Fujihara","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Radiology and Neurology, Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Koriyama, Fukushima, 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