{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:57:37Z","timestamp":1777507057764,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nishikawa Medical foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Moyamoya disease (MMD) and non-MMD have different pathogenesis, clinical presentation, and treatment policy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify differences in hemodynamics between MMD and non-MMD using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Patients who had undergone\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-ECD or\n                      <jats:sup>123<\/jats:sup>\n                      I-IMP SPECT, and IVIM imaging were retrospectively studied. IVIM imaging was acquired using six different b-values. Cerebral blood flow ratio (CBF\n                      <jats:sub>R<\/jats:sub>\n                      ) in the basal ganglia was calculated using a standardized volume-of-interest template. The cerebellum was used as a reference region. IVIM perfusion fraction (f) was obtained using a two-step fitting algorithm. Elliptical regions of interest were placed in bilateral basal ganglia on the IVIM f map. Patients were classified into MMD and non-MMD groups. The correlation between CBF\n                      <jats:sub>R<\/jats:sub>\n                      and mean IVIM f (f\n                      <jats:sub>mean<\/jats:sub>\n                      ) in the basal ganglia was evaluated using Spearman's rank correlation coefficient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 20 patients with MMD and 28 non-MMD patients were analyzed. No significant differences in f\n                      <jats:sub>mean<\/jats:sub>\n                      were observed among MMD, affected hemisphere with non-MMD (non-MMD\n                      <jats:sub>aff<\/jats:sub>\n                      ), and unaffected hemispheres with non-MMD (non-MMD\n                      <jats:sub>unaff<\/jats:sub>\n                      ). A negative correlation was seen between f\n                      <jats:sub>mean<\/jats:sub>\n                      and CBF\n                      <jats:sub>R<\/jats:sub>\n                      in the MMD group (r\u2009=\u2009\u20130.40, P\u2009=\u20090.0108), but not in the non-MMD group (non-MMD\n                      <jats:sub>aff<\/jats:sub>\n                      , r\u2009=\u20090.07, P\u2009=\u20090.69; non-MMD\n                      <jats:sub>unaff<\/jats:sub>\n                      , r\u2009=\u2009\u20130.22, P\u2009=\u20090.29). No significant differences were found among MMD and non-MMD patients, irrespective of SPECT tracers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of IVIM MRI and SPECT appears to allow non-invasive identification of differences in hemodynamics between MMD and non-MMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851221092895","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T02:03:41Z","timestamp":1650852221000},"page":"769-775","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Different hemodynamics of basal ganglia between moyamoya and non-moyamoya diseases using intravoxel incoherent motion imaging and single-photon emission computed tomography"],"prefix":"10.1177","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-739X","authenticated-orcid":false,"given":"Koji","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Radiology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sugimori","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Nakamizo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kuwashiro","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeharu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Division of Radiology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kawamata","sequence":"additional","affiliation":[{"name":"Department of 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