{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:58:57Z","timestamp":1777507137293,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Magnetic resonance diffusion tensor imaging (MR-DTI) has been increasingly applied for carpal tunnel syndrome (CTS) diagnosis, but relatively little is known about the effect of CTS treatment on median nerve (MN) integrity and functional outcome prediction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess how structural changes in MR-DTI of the MN correlates with symptom severity, functional status, and electrophysiological parameters in patients suffering from CTS before and after decompression surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Nine wrists were prospectively enrolled to perform MR-DTI pre- and postoperatively. The apparent diffusion coefficients (ADC) and fractional anisotropy (FA) of the MN were examined in three different regions\u2014distal radioulnar joint, pisiform bone, and hamate bone\u2014and correlated with clinical and electrophysiological parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postoperatively, mean Boston Carpal Tunnel Questionnaire scores decreased 1.55 points (range = 0.08\u20133; P\u2009=\u20090.0172) and 1.01 points (\u22120.13 to 1.88; P\u2009=\u20090.0381) in the symptomatic and functional domains, respectively. Postoperative clinical improvement was reflected in proximal FA elevation ( P\u2009=\u20090.0078), but not in diffusivity in comparison to baseline examination. Preoperative electrophysiological parameters were correlated with a reduction in the pre- (sensory latencies [rho\u2009=\u2009\u20130.6826; P\u2009=\u20090.0312]) and postoperative (motor latencies [rho\u2009=\u2009\u20130.7488; P\u2009=\u20090.0325]) distal FA values. Higher sensory amplitudes indicated higher postoperative proximal FA values (rho\u2009=\u20090.7618; P\u2009=\u20090.0280) \u200b\u200band lower postoperative proximal ADC values (rho\u2009=\u2009\u20130.9047; P\u2009=\u20090.0020).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrated that pre- and postoperative proximal FA values are useful biomarkers for the structural evaluation of the MN in patients with CTS. Symptomatic improvement can be better predicted by analyzing FA changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851221113518","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T07:26:53Z","timestamp":1658734013000},"page":"1109-1115","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of diffusion tensor imaging as a prognostic biomarker after decompression surgery for carpal tunnel syndrome"],"prefix":"10.1177","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9766-1344","authenticated-orcid":false,"given":"F\u00e1bio Henrique","family":"Pinto da Silva","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Hospital Naval Marcilio Dias, Rio de Janeiro, Brazil"},{"name":"Postgraduation Program in Neurology, Federal University of the State of Rio de Janeiro (UNIRIO)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4216-333X","authenticated-orcid":false,"given":"Jonadab","family":"dos Santos Silva","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Fluminense Federal University, Niter\u00f3i \u2013 Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Fidalgo","family":"Pereira de Barros","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Fluminense Federal University, Niter\u00f3i \u2013 Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renan de Freitas","family":"Souza","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Fluminense Federal University, Niter\u00f3i \u2013 Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alberto","family":"Landeiro","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Fluminense Federal University, Niter\u00f3i \u2013 Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Cristina","family":"Rueda Lopes","sequence":"additional","affiliation":[{"name":"Division of Radiology, DASA, Rio de Janeiro, Brazil"},{"name":"Division of Radiology, Fluminense Federal University, Niter\u00f3i \u2013 Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Bernardes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Division of Radiology, DASA, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana Vasconcelos de Souza","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisas Biom\u00e9dicas, Hospital Naval Marcilio Dias, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Andr\u00e9","family":"Acioly","sequence":"additional","affiliation":[{"name":"Postgraduation Program in Neurology, Federal University of the State of Rio de Janeiro (UNIRIO)"},{"name":"Division of Neurosurgery, Fluminense Federal University, Niter\u00f3i \u2013 Rio de Janeiro, Brazil"},{"name":"Division of Neurosurgery, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"bibr1-02841851221113518","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.2.153"},{"key":"bibr2-02841851221113518","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20261"},{"key":"bibr3-02841851221113518","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00719"},{"key":"bibr4-02841851221113518","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(05)80265-5"},{"key":"bibr5-02841851221113518","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004857"},{"key":"bibr6-02841851221113518","unstructured":"Spinner M. 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