{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:14:05Z","timestamp":1784304845181,"version":"3.55.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prior studies have shown abnormal brain functional network changes in patients with acute ischemic stroke. However, the alterations of dynamic functional network connectivity (FNC) in brainstem strokes have not been elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess alterations of static and dynamic FNCs and determine the relationships between these and upper limb movement performance in patients with acute brainstem ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In total, 50 patients with acute brainstem ischemic stroke and 50 age- and sex-matched healthy controls were enrolled in the present study and underwent resting-state functional magnetic resonance imaging (rs-fMRI). Independent component analysis was conducted to assess static and dynamic FNC patterns based on seven resting-state networks, namely, the default mode network (DMN), executive control network (ECN), attention network (AN), somatomotor network (SMN), visual network (VN), auditory network (AUN), and cerebellum network (CN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with controls, patients with acute brainstem ischemic stroke exhibited wide aberrations of static FNC, including increased FNC in DMN\u2013ECN, DMN\u2013VN, ECN\u2013VN, ECN\u2013AN and AN\u2013AUN pairs. Patients with acute brainstem ischemic stroke showed aberrant dynamic FNC in State 1, involving increased FNC aberrance in the DMN with AN, DMN with ECN, and reduced FNC in SMN\u2013VN pairs. In State 5, patients with acute brainstem ischemic stroke showed increased FNC in DMN\u2013VN and AN\u2013AUN, and decreased FNC in AN\u2013SMN pairs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that static and dynamic FNC impairment and aberrant connections exist in acute brainstem ischemic stroke, which expands what is known regarding the relationship between stroke and FNC from static and dynamic perspectives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851221127271","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T12:30:30Z","timestamp":1663331430000},"page":"1623-1630","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Alterations of static and dynamic functional network connectivity in acute ischemic brainstem 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