{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:59:52Z","timestamp":1777507192907,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T00:00:00Z","timestamp":1673136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"SIAD"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early detection can prevent the initial stages of fibrosis from progressing to cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate an algorithm combining three echographic indicators and elastographic measurements to screen for hepatic fibrosis in an unselected population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      From May 2017 to June 2018, all patients with no history and no known chronic liver disease who were referred for an ultrasound (US) were prospectively included in eight hospitals. The indicators being sought were liver surface irregularity, demodulation of hepatic veins, and spleen length &gt;110 mm. Patients presenting at least one of these underwent elastography measurements with virtual touch quantification (VTQ) or supersonic shear imaging (SSI). If elastography was positive, patients were referred to hepatologist for fibrosis evaluation. Reference standard was obtained by FibroMeter\n                      <jats:sup>VCTE<\/jats:sup>\n                      or biopsy. A FibroMeter\n                      <jats:sup>VCTE<\/jats:sup>\n                      result &gt;0.384 indicated a \u201cnecessary referral\u201d to a hepatologist.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 1501 patients included, 504 (33.6%) were positive for at least one US indicator. All of them underwent US elastography, with 85 being positive. Of the patients, 58 (3.6%) had a consultation with a liver specialist: 21 had positive FibroMeter\n                      <jats:sup>VCTE<\/jats:sup>\n                      and nine had an indication of biopsy for suspicion of fibrosis. This screening algorithm made it possible to diagnose 1.6% of patients in our population with unknown fibrosis. Of the patients, 50% referred to the liver specialist were \u201cnecessary referrals.\u201d\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that three simple US indicators with no systematic elastographic measurement could be applied in day-to-day practice to look for hepatic fibrosis in an unsuspected population allowing relevant referrals to a hepatologist.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851221138519","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T02:58:43Z","timestamp":1673233123000},"page":"1730-1737","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of a screening algorithm for hepatic fibrosis by Doppler ultrasound and elastography in a general population"],"prefix":"10.1177","volume":"64","author":[{"given":"Anne-Sophie","family":"Renard","sequence":"first","affiliation":[{"name":"Department of Radiology, Angers University Hospital, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0308-2833","authenticated-orcid":false,"given":"Anita","family":"Paisant","sequence":"additional","affiliation":[{"name":"Department of Radiology, Angers University Hospital, Angers, France"},{"name":"HIFIH Laboratory, EA 3859, UNIV Angers, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoire","family":"Cartier","sequence":"additional","affiliation":[{"name":"Department of Radiology, Angers University Hospital, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cal\u00e8s","sequence":"additional","affiliation":[{"name":"HIFIH Laboratory, EA 3859, UNIV Angers, Angers, France"},{"name":"Department of Hepatology, Angers University Hospital, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirela","family":"Goyet-Prelipcean","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cholet Hospital, Cholet, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond","family":"Geagea","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Cholet Hospital, Cholet, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Tasu","sequence":"additional","affiliation":[{"name":"Department of Radiology, CHU de Poitiers, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Silvain","sequence":"additional","affiliation":[{"name":"Department of Hepatology, CHU de Poitiers, Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Wagner","sequence":"additional","affiliation":[{"name":"UPMC, Department of Radiology, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Sorbonne Universit\u00e9s, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Le","family":"Cleach","sequence":"additional","affiliation":[{"name":"UPMC, Department of Hepatology, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Sorbonne Universit\u00e9s, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Vilgrain","sequence":"additional","affiliation":[{"name":"Department of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, France"},{"name":"University Paris Diderot. Sorbonne Paris Cit\u00e9, INSERM U1149, CRI, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Castera","sequence":"additional","affiliation":[{"name":"Department of Hepatology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Bricault","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University Hospital, Grenoble, France"},{"name":"Laboratory of Techniques for Biomedical Engineering and Complexity Management, University Grenoble Alpes \/ National Center for Scientific Research, Grenoble, France"},{"name":"Clinical Investigation Center \u2013 Innovative Technology 1406, National Institute of Health and Medical Research \/ Research Department, University Hospital, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Decaens","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Grenoble, France"},{"name":"Institute for Advanced Biosciences, Research Center UGA\/Inserm U 1209\/CNRS 5309, La Tronche, France"},{"name":"Department of Hepatology, P\u00f4le Digidune, CHU Grenoble Alpes, La Tronche, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Savoye-Collet","sequence":"additional","affiliation":[{"name":"Department of Radiology, Rouen University Hospital, Normandie Univ, UNIROUEN, Quantif-LITIS EA 4108, Rouen cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Montialoux","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Rouen University Hospital, Rouen cedex, 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