{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:21:52Z","timestamp":1783948912949,"version":"3.55.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome associated with phosphaturic mesenchymal tumors (PMTs). Localization of the causative tumor in these cases is an arduous task since the culprit lesions are usually small, slow-growing, and can be located almost anywhere from head to toe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe the morphological characteristics of histologically proven PMTs on various radiological modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>After institutional ethical approval, this retrospective study analyzed 20 cases with a histopathological evidence of PMT. Various imaging characteristics of the tumors on available computed tomography (CT) and magnetic resonance imaging (MRI) scans were evaluated. Descriptive statistical analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The tumors were located in diverse locations: lower extremities (n\u2009=\u200910); head and neck (n\u2009=\u20095); vertebral column (n\u2009=\u20093); pelvis (n\u2009=\u20091); and upper extremities (n\u2009=\u20091). Bone lesions seen on CT had variable morphology: sclerotic (n\u2009=\u20093\/8, 37.5%); lytic (n\u2009=\u20093\/8, 37.5%), and both lytic and sclerotic (n\u2009=\u20092\/8, 25%) with presence of narrow zone of transition in all cases (n\u2009=\u20098\/8) and amorphous internal matrix calcifications in 25% of cases (n\u2009=\u20092\/8). Of the tumors, 68.4% (n\u2009=\u200913\/19) were hypointense on T1 and all of them showed hyperintense signal on T2-weighted and STIR images (n\u2009=\u200919\/19) and contrast enhancement (n\u2009=\u200916\/16). Of the tumors, 66.7% (n\u2009=\u20096\/9) showed restricted diffusion. DOTANOC PET\/CT showed tumor uptake in all cases (n\u2009=\u20098\/8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PMTs may have variable and non-specific tumor appearances on various imaging modalities. However, in an appropriate clinical scenario and a background of suggestive biochemical work-up, the radiologist should keep a high index of suspicion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851231160086","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T02:19:59Z","timestamp":1678760399000},"page":"2061-2073","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Imaging characteristics of phosphaturic mesenchymal tumors"],"prefix":"10.1177","volume":"64","author":[{"given":"Amit","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-4937","authenticated-orcid":false,"given":"Devasenathipathy","family":"Kandasamy","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishikant","family":"Damle","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3333-3701","authenticated-orcid":false,"given":"Ankur","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpesh","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-4444","authenticated-orcid":false,"given":"Shipra","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamini","family":"Dharmashaktu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"bibr1-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-020-00691-6"},{"key":"bibr2-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1642"},{"key":"bibr3-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1260"},{"key":"bibr4-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200401000-00001"},{"key":"bibr5-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.29.69"},{"key":"bibr6-02841851231160086","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2017.031"},{"key":"bibr7-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe030037"},{"key":"bibr8-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3178-1"},{"key":"bibr9-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.44"},{"key":"bibr10-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0006"},{"key":"bibr11-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10178"},{"key":"bibr12-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4515"},{"key":"bibr13-02841851231160086","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2081"},{"key":"bibr14-02841851231160086","doi-asserted-by":"publisher","DOI":"10.4158\/EP151029.CR"},{"key":"bibr15-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1159\/000510334"},{"key":"bibr16-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1210\/js.2016-1088"},{"key":"bibr17-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-015-0763-7"},{"key":"bibr18-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2019.04.007"},{"key":"bibr19-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1881"},{"key":"bibr20-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00170-2"},{"key":"bibr21-02841851231160086","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.167.2.8686600"},{"key":"bibr22-02841851231160086","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.2011-0006"},{"key":"bibr23-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-018-3014-5"},{"key":"bibr24-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1007\/s43465-019-00005-5"},{"key":"bibr25-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10090702"},{"key":"bibr26-02841851231160086","first-page":"4970","volume":"15","author":"Shi Z","year":"2018","journal-title":"Oncol Lett"},{"key":"bibr27-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3415-4"},{"key":"bibr28-02841851231160086","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2014.5.0100"},{"key":"bibr29-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-021-01412-1"},{"key":"bibr30-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.01.004"},{"key":"bibr31-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-015-2246-x"},{"key":"bibr32-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1446-z"},{"key":"bibr33-02841851231160086","first-page":"E11","volume":"89","author":"Peterson NR","year":"2010","journal-title":"Ear Nose Throat J"},{"key":"bibr34-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2020-0079"},{"key":"bibr35-02841851231160086","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2052"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851231160086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02841851231160086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851231160086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:33:23Z","timestamp":1777390403000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02841851231160086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1177\/02841851231160086"],"URL":"https:\/\/doi.org\/10.1177\/02841851231160086","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]}}}