{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:52:29Z","timestamp":1781841149611,"version":"3.54.5"},"reference-count":19,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260241"],"award-info":[{"award-number":["32260241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Computed tomography (CT) value studies of cone-beam breast CT (CBBCT) mainly focus on the enhancement value or enhancement rate, and there has been no study on the CT value (Hounsfield units [HU]) of the lesion itself.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the CT values under contrast-enhanced CBBCT (CE-CBBCT) and non-contrast-enhanced CBBCT (NC-CBBCT) in scanning for the differential diagnosis of benign and malignant breast lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on 189 cases of mammary glandular tissues that underwent NC-CBBCT and CE-CBBCT examination. The qualitative CT values of the lesions, standardized \u0394(L-A), standardized \u0394*(L - G), standardized \u0394(L-A) (Post 1st-Pre), and standardized \u0394*(L-G) (Post 2nd-Post 1st) between the benign and malignant groups were compared. Prediction performance was evaluated using receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 58 cases were included in the benign group, 79 cases were included in the malignant group, and 52 cases were included in the normal group. The best diagnostic thresholds of CT values for L (Post 1st-Pre), \u0394(L-A) (Post 1st-Pre), and \u0394*(L-G) (Post 1st-Pre) were 49.5, 44, and 64.8 HU, respectively. The \u0394(L-A) Post-1st rate values of CBBCT had medium diagnostic efficacy (AUC\u2009=\u20090.74, sensitivity\u2009=\u200976.6%, specificity\u2009=\u200969.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CE-CBBCT can improve the diagnostic efficiency of breast lesions compared with NC-CBBCT. The CT values (HU) of lesions do not need to be standardized with fat and can be directly used in clinical differential diagnosis. The first contrast phase (60 s) is recommended to reduce the radiation exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851231177379","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T02:53:40Z","timestamp":1686192820000},"page":"2379-2386","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["CT values of contrast-enhanced CBBCT: A useful diagnostic tool for benign and malignant breast lesions"],"prefix":"10.1177","volume":"64","author":[{"given":"Wei","family":"Wei","sequence":"first","affiliation":[{"name":"Medical imaging Department, Guangxi Medical University Cancer Hospital and Guangxi Cancer Research Institute, Nanning, PR China"},{"name":"Guangxi Key Clinical Specialty (Medical imaging Department), Nanning, PR China"},{"name":"Dominant Cultivation Discipline of Guangxi Medical University Cancer Hospital (Medical imaging Department), PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-3784","authenticated-orcid":false,"given":"Xian Lin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of urology, WuMing Hospital of Guangxi Medical University, Nanning, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical imaging Department, Guangxi Medical University Cancer Hospital and Guangxi Cancer Research Institute, Nanning, PR China"},{"name":"Guangxi Key Clinical Specialty (Medical imaging Department), Nanning, PR China"},{"name":"Dominant Cultivation Discipline of Guangxi Medical University Cancer Hospital (Medical imaging Department), PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Liao","sequence":"additional","affiliation":[{"name":"Medical imaging Department, Guangxi Medical University Cancer Hospital and Guangxi Cancer Research Institute, Nanning, PR China"},{"name":"Guangxi Key Clinical Specialty (Medical imaging Department), Nanning, PR China"},{"name":"Dominant Cultivation Discipline of Guangxi Medical University Cancer Hospital (Medical imaging Department), PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4792-8530","authenticated-orcid":false,"given":"DanKe","family":"Su","sequence":"additional","affiliation":[{"name":"Medical imaging Department, Guangxi Medical University Cancer Hospital and Guangxi Cancer Research Institute, Nanning, PR China"},{"name":"Guangxi Key Clinical Specialty (Medical imaging Department), Nanning, PR China"},{"name":"Dominant Cultivation Discipline of Guangxi Medical University Cancer Hospital (Medical imaging Department), PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"bibr1-02841851231177379","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21203"},{"key":"bibr2-02841851231177379","volume":"10","author":"O\u2019Connell AM","year":"2021","journal-title":"J Clin Med"},{"key":"bibr3-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210466"},{"key":"bibr4-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.05.032"},{"key":"bibr5-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20181034"},{"key":"bibr6-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1177\/0284185120963923"},{"key":"bibr7-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08699-2"},{"key":"bibr8-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5711-9"},{"key":"bibr9-02841851231177379","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.868975"},{"key":"bibr10-02841851231177379","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S312288"},{"key":"bibr11-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5376-4"},{"key":"bibr12-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08178-0"},{"key":"bibr13-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5854-8"},{"key":"bibr14-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1002\/mp.15374"},{"key":"bibr15-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.09.020"},{"key":"bibr16-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10092311"},{"key":"bibr17-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.12.003"},{"key":"bibr18-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12285"},{"key":"bibr19-02841851231177379","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2020.01.001"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851231177379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02841851231177379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851231177379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:33:30Z","timestamp":1777390410000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/02841851231177379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1177\/02841851231177379"],"URL":"https:\/\/doi.org\/10.1177\/02841851231177379","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]}}}