{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:33:33Z","timestamp":1777509213591,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The National Science Foundation of China"},{"name":"the Beijing Municipal Natural Science Foundation for Distinguished Young Scholars"},{"name":"the Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-invasive determination of H3 K27 alteration of pediatric brainstem glioma (pedBSG) remains a clinical challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To predict H3 K27-altered pedBSG using amide proton transfer-weighted (APTw) imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This retrospective study included patients with pedBSG who underwent APTw imaging and had the H3 K27 alteration status determined by immunohistochemical staining. The presence or absence of foci of markedly increased APTw signal in the lesion was visually assessed. Quantitative APTw histogram parameters within the entire solid portion of tumors were extracted and compared between H3 K27-altered and wild-type groups using Student's t-test. The ability of APTw for differential diagnosis was evaluated using logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty pedBSG patients included 48 patients with H3 K27-altered tumor (aged 2\u201348\u2005years) and 12 patients with wild-type tumor (aged 3\u201353\u2005years). Visual assessment showed that the foci of markedly increased APTw signal intensity were more common in the H3 K27-altered group than in wild-type group (60% vs. 16%, P\u2009=\u20090.007). Histogram parameters of APTw signal intensity in the H3 K27-altered group were significantly higher than those in the wild-type group (median, 2.74% vs. 2.22%, P\u2009=\u20090.02). The maximum (area under the receiver operating characteristic curve [AUC]\u2009=\u20090.72, P\u2009=\u20090.01) showed the highest diagnostic performance among histogram analysis. A combination of age, median and maximum APTw signal intensity could predict H3 K27 alteration with a sensitivity of 81%, specificity of 75% and AUC of 0.80.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>APTw imaging may serve as an imaging biomarker for H3 K27 alteration of pedBSGs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851231197503","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T20:59:50Z","timestamp":1695070790000},"page":"2922-2930","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Amide proton transfer-weighted imaging of pediatric brainstem glioma and its predicted value for H3 K27 alteration"],"prefix":"10.1177","volume":"64","author":[{"given":"Dan","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhizheng","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Haller","sequence":"additional","affiliation":[{"name":"Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"UCL Institutes of Neurology and Healthcare Engineering, London, UK"},{"name":"Department of Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4352-5774","authenticated-orcid":false,"given":"Yaou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 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