{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:30:25Z","timestamp":1790447425468,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuroprotective agents are needed to reduce cerebral damage during surgical or neurointerventional procedures including stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate if thiopental can be used as a neuroprotective agent when injected intra-arterially in a transient ischemia model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In total, 24 rabbits were studied as four groups of six animals. Group 1 served as the control group. In group 2, transient ischemia was obtained by intracarotid administration of degradable starch microspheres (DSM). Group 3 was administered thiopental intra-arterially via the carotid artery. Group 4 (experimental group) received both thiopental and DSM intra-arterially. DSM and thiopental were administered through a microcatheter placed into the common carotid artery via the central ear artery access. After sacrifice, apoptotic cells in the cerebral tissues of the animals were evaluated in H&amp;E and TUNEL stained slides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a significant increase in the number of apoptotic glial or neuronal cells in group 2 compared to the control group and group 3. The mean number of both the apoptotic neuronal cells (6.8\u2009\u00b1\u20092.1 vs. 2.5\u2009\u00b1\u20091.3, P\u2009&lt;\u20090.001) and the apoptotic glial cells (9.4\u2009\u00b1\u20093.1 vs. 4.6\u2009\u00b1\u20091.6, P\u2009&lt;\u20090.001) were higher in group 2 compared to group 4. In addition, a higher level of neurological improvement was observed in group 4 compared to group 2 based on neurological assessment score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The intra-arterial administration of thiopental has a protective effect on both glial and neuronal cells during temporary cerebral ischemia in low doses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851231206503","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:23:00Z","timestamp":1698106980000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["In vivo study of the utility of selective intra-arterial injection of thiopental for neuroprotection in reversible cerebral ischemia"],"prefix":"10.1177","volume":"65","author":[{"given":"Murat","family":"G\u00f6kten","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Corlu State Hospital, Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5234-1921","authenticated-orcid":false,"given":"Osman","family":"\u00d6cal","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hacettepe University, Ankara, Turkey"},{"name":"Department of Radiology, University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Sezer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seyhan State Hospital, Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Z\u0131rh","sequence":"additional","affiliation":[{"name":"Department of Histology, Binali Y\u0131ld\u0131r\u0131m University, Erzincan, 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