{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:08:40Z","timestamp":1780628920182,"version":"3.54.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["2020081"],"award-info":[{"award-number":["2020081"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In acromegaly, the primary tumor is usually found during magnetic resonance imaging (MRI) of the pituitary gland. A remnant tumor after surgery is, however, harder to depict. When a tumor is missed, the remaining option is usually lifelong pharmacological treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify tumors by reassessment of all available MRI scans in pharmacologically treated patients, operated or not, and to compare our results with the routine MRI reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Adult patients diagnosed with acromegaly and managed at a tertiary care center between 2005 and 2021 and currently on pharmacological treatment were included. MRI scans were evaluated in a standardized manner and classified independently by a radiologist and an endocrinologist into \u201ccertain,\u201d \u201csuspected,\u201d or \u201cno tumor.\u201d In case of disagreement, consensus was achieved with a senior neuroradiologist. The results were compared using the clinical radiologists\u2019 routine MRI reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified certain and suspected tumors in 29\/74 and 36\/74 patients, respectively. No tumor was identified in nine patients. In five of these, no MRI contrast agent was given. Discrepancy between our results and the routine MRI reports was found in 31\/74 patients ( P\u2009=\u20090.01). In 22 patients, the routine reports described no tumor while we identified certain tumors in 2\/22 patients and suspected tumors in 13\/22 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In most patients with pharmacologically treated acromegaly, we identified a certain or suspected pituitary tumor. These findings were more frequent compared to the routine MRI reports. Based on our results, patients will be considered for a change in long-term treatment modality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851241246107","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T02:20:57Z","timestamp":1714011657000},"page":"753-758","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Unravelling pituitary tumours in medically treated patients with acromegaly: the impact of systematic MRI reassessment"],"prefix":"10.1177","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6818-1076","authenticated-orcid":false,"given":"Shahriar","family":"Atai","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Oslo University Hospital, Oslo, Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Knudtzon Andersen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oslo University Hospital, Oslo, Norway"},{"name":"Department of Radiology, Diakonhjemmet Hospital, Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wiedmann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dahlberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin Astrid B","family":"\u00d8ystese","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bollerslev","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Ringstad","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oslo University Hospital, Oslo, Norway"},{"name":"Department of Geriatrics and Internal medicine, Sorlandet Hospital, Arendal, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-884X","authenticated-orcid":false,"given":"Ansgar","family":"Heck","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Oslo University Hospital, Oslo, 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