{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:59:35Z","timestamp":1792828775170,"version":"4.5.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>68Ga-labled fibroblast activating protein inhibitor (68Ga-FAPI) represents a new and exciting positron emission tomography-computed tomography\/magnetic resonance (PET-CT\/MR) radiotracer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the diagnostic efficacy of 68Ga-FAPI PET CT\/MR and 18F-fluorodeoxyglucose (18F-FDG) PET\/CT in metastatic lesions of gynecological cancers (GCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>The PubMed, Embase, and Web of Science databases were thoroughly investigated from inception until 22 December 2023. A head-to-head contrast between 18F-FDG PET\/CT as well as 68Ga-FAPI PET CT\/MR for the assessment of GCs was presented by the included studies. A random variable model was employed to examine the sensitivity in detection of lymph node (LN) and peritoneal metastases (PM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The pooled sensitivity for 68Ga-FAPI PET CT\/MR and 18F-FDG PET\/CT in lymph node metastases (LNM) of GC were 0.98 (95% confidence interval [CI] = 0.86\u20131) and 0.85 (95% CI = 0.65\u20130.98), respectively, while the results about peritoneal metastases in ovarian cancer were 0.98 (95% CI = 0.93\u20131) and 0.71 (95% CI = 0.55\u20130.86). Compared with 18F-FDG PET\/CT, 68Ga-FAPI PET CT\/MR exhibited a better sensitivity in peritoneal involvement of ovarian cancer with a relative risk of 0.24 (95% CI = 0.09\u20130.40) and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>68Ga-FAPI PET CT\/MR displayed a superior sensitivity over 18F-FDG PET\/CT in detecting metastatic lesions of ovarian cancer. However, there was insufficient evidence to favor the superiority of 68Ga-FAPI PET CT\/MR in LNM of CC. Further studies are needed for evaluating primary and metastatic lesions of 68Ga-FAPI PET CT\/MR in different GC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851241297836","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T02:10:01Z","timestamp":1734315001000},"page":"174-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of 68Ga-FAPI PET CT\/MRI and 18F-FDG PET\/CT in metastatic lesions of gynecological cancers: a systematic review and head-to-head meta-analysis"],"prefix":"10.1177","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-6741","authenticated-orcid":false,"given":"Lixin","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-0453","authenticated-orcid":false,"given":"Ruchen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_2_3_2","first-page":"117","article-title":"MRI and FDG-PET\/CT imaging in gynecological malignancies: the radiation oncology perspective","volume":"60","author":"Fennell J","year":"2016","unstructured":"Fennell J, Scholber J, Grosu AL, et al. 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