{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:05:53Z","timestamp":1782795953419,"version":"3.54.5"},"reference-count":74,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The comparative diagnostic performance of\n                      <jats:sup>68<\/jats:sup>\n                      Gallium (Ga)-PSMA-11 PET\/CT and\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA-11 PET\/MRI in detecting bone metastases in prostate cancer (PCa) remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To systematically evaluate the early detection rate of biochemical recurrent (BCR) bone metastasis in PCa utilizing\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA-11 PET\/CT and\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA-11 PET\/MRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      We searched PubMed, Embase, and Web of Science for relevant articles up to April 2023 and extracted studies that examined the positivity rate of both\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA-11 PET\/CT and\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA-11 PET\/MRI in the context of the BCR bone metastasis of PCa patients. Random-effects model was used to compare positivity rates for two imaging modalities. Heterogeneity among studies was assessed using the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      statistic. To evaluate the methodological quality of studies, we employed Quality Assessment of Diagnostic Performance Studies method. The study protocol was registered in PROSPERO (CRD42023454118).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1670 publications were originally identified; 58 studies, encompassing a cohort of 8037 patients, met the inclusion criteria. Regarding the evaluation of BCR bone metastasis, results suggest no statistically significant difference in the utilization of\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA-11 PET\/CT versus\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA-11 PET\/MRI in 58 non\u2013head-to-head studies (0.21, 95% CI=0.19\u20130.24 and 0.17, 95% CI=0.11\u20130.23;\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20090.19) and four head-to-head studies (0.16, 95% CI=0.08\u20130.27 and 0.16, 95% CI=0.08\u20130.27;\n                      <jats:italic>P\u2009<\/jats:italic>\n                      =\u20091.00). Meta-regression showed the study design of influenced the heterogeneity in the PET\/MRI group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01); but analysis of PET\/CT did not identify the potential reason for heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      There was no statistically significant difference in identifying BCR bone metastasis in PCa patients between\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA-11 PET\/CT and\n                      <jats:sup>68<\/jats:sup>\n                      Ga-PSMA-11 PET\/MRI.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851241307336","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T12:48:17Z","timestamp":1738154897000},"page":"312-327","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative diagnostic performance of\n                    <sup>68<\/sup>\n                    Ga-PSMA-11 PET\/CT and\n                    <sup>68<\/sup>\n                    Ga-PSMA-11 PET\/MRI in detecting biochemical recurrent bone metastasis in prostate cancer: a systematic review and meta-analysis"],"prefix":"10.1177","volume":"66","author":[{"given":"Xin","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-2091","authenticated-orcid":false,"given":"Meng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2403-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)69079-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000134888.22332.bb"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.09.005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.18481"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.03.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.261866"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05433-w"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-016-3435-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.261886"},{"key":"e_1_3_2_13_2","first-page":"1288","article-title":"NCCN guidelines(R) insights: prostate cancer, version 1.2023","volume":"20","author":"Schaeffer EM","year":"2022","unstructured":"Schaeffer EM, Srinivas S, Adra N, et al. 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