{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:23:22Z","timestamp":1790965402972,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Different parotid tumors differ in terms of treatment strategies due to their distinct biological behaviors. Time-dependent diffusion magnetic resonance imaging (t\n                      <jats:sub>d<\/jats:sub>\n                      -dMRI) can characterize and quantify the cytological indexes, and then aid the differential diagnosis of various tumors. However, the value of t\n                      <jats:sub>d<\/jats:sub>\n                      -dMRI in the analysis of parotid gland tumors remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To investigate the value of quantitative parameters derived from t\n                      <jats:sub>d<\/jats:sub>\n                      -dMRI in the analysis of parotid gland tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      In total, 39 patients with parotid gland tumors were prospectively enrolled, including 24 patients with polymorphic adenomas (PAs), eight with Warthin's tumors (WTs), and seven with malignant tumors (MTs). T\n                      <jats:sub>d<\/jats:sub>\n                      -dMRI was performed for preoperative evaluation. Intracellular volume fraction (\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>in<\/jats:sub>\n                      ), mean cell size (\n                      <jats:italic>d<\/jats:italic>\n                      ), extracellular diffusion coefficient (\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>ex<\/jats:sub>\n                      ), and cellularity were obtained based on the Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion model, and compared among the three groups. One-way ANOVA, Kruskal\u2013Wallis test, and receiver operating characteristic (ROC) curve analysis were performed for further statistical analysis as appropriate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences were found in all t\n                      <jats:sub>d<\/jats:sub>\n                      -dMRI-derived indexes among PAs, WTs, and MTs (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>in<\/jats:sub>\n                      was the sole parameter with significant differences for all sub-group comparisons (PAs vs. WTs,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001; PAs vs. MTs,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031; WTs vs. MTs,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.047). With\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>in<\/jats:sub>\n                      values of 0.267, 0.231, and 0.260 as threshold, respectively, optimal performance levels were obtained for differentiating PAs from WTs (area under the ROC curve [AUC]=0.932, sensitivity=0.917, and specificity=0.875), PAs from MTs (AUC=0.744, sensitivity=0.833, and specificity=0.714), and WTs from MTs (AUC=0.750, sensitivity=0.875, and specificity=0.714).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Microstructural parameters derived from t\n                      <jats:sub>d<\/jats:sub>\n                      -dMRI, especially\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>in<\/jats:sub>\n                      , might be promising imaging biomarkers for characterizing parotid gland tumors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/02841851241313108","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:24:47Z","timestamp":1737437087000},"page":"505-511","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Time-dependent diffusion magnetic resonance imaging for the analysis of parotid gland tumors"],"prefix":"10.1177","volume":"66","author":[{"given":"Di","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, PR China"},{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Ning","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Ce","family":"Zhao","sequence":"additional","affiliation":[{"name":"Philips Healthcare, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Shi","family":"Wang","sequence":"additional","affiliation":[{"name":"MR Collaboration, Siemens Healthineers Ltd, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-5256","authenticated-orcid":false,"given":"Xiao-Quan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0343-0458","authenticated-orcid":false,"given":"Fei-Yun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carj.2018.10.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27061"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000566"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0222-RA"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041325"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.02.020"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrnm.2018.03.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-4895-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2017.00058"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4329\/wjr.v15.i1.20"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3755-7"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11282-015-0203-y"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25684"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2020.12.010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26578"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28056"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26356"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-017-1176-6"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2022.06.017"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2309-8"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","unstructured":"Chen W Zhu LN Dai YM et al. Differentiation of salivary gland tumor using diffusion-weighted imaging with a fractional order calculus model. Br J Radiol 2020;93:20200052.","DOI":"10.1259\/bjr.20200052"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330516"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.436751"},{"key":"e_1_3_2_27_2","first-page":"312","article-title":"A study of fine needle aspiration cytology of salivary gland lesions with histopathological corroboration","volume":"103","author":"Bandyopadhyay A","year":"2005","unstructured":"Bandyopadhyay A, Das TK, Raha K, et al. A study of fine needle aspiration cytology of salivary gland lesions with histopathological corroboration. J Indian Med Assoc 2005;103:312\u2013316.","journal-title":"J Indian Med Assoc"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-4895-6"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/00368504211018583"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2015.1081276"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.18492"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28454"}],"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851241313108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/02841851241313108","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/02841851241313108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:34:29Z","timestamp":1777390469000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/02841851241313108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/02841851241313108"],"URL":"https:\/\/doi.org\/10.1177\/02841851241313108","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]}}}